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(S)-(+)-Ibuprofen

Catalog No. T0448 CAS 51146-56-6

Synonyms: (S)-Ibuprofen, Dexibuprofen

Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).

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(S)-(+)-Ibuprofen, CAS 51146-56-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Dexibuprofen, S(+)-ibuprofen, is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).
Targets&IC50	COX-1:13 μM, COX-2:370 μM

Synonyms	(S)-Ibuprofen, Dexibuprofen
Molecular Weight	206.28
Formula	C13H18O2
CAS No.	51146-56-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 25 mg/mL (121.19 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Sanchez-Fidalgo S, et al. Eur J Pharmacol. 2004 Nov 28; 505(1-3):187-94.

Dose Conversion

You can also refer to dose conversion for different animals. More

In vivo Formulation Calculator (Clear solution)

Step One: Enter information below

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Step Two: Enter the in vivo formulation

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
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The answer of 19.713 mg appears in the Mass box

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Calculator the dilution required to prepare a stock solution

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The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

(S)-(+)-Ibuprofen 51146-56-6 Apoptosis DNA Damage/DNA Repair Immunology/Inflammation Metabolism Neuroscience Proteases/Proteasome PPAR Thrombin COX BCL Cysteine Protease S(+)-enantiomer COX-1 Inhibitor analgesic (S)-Ibuprofen Dexibuprofen inhibit NF-κB COX-2 Cyclooxygenase (S) (+) Ibuprofen antipyretic (S)(+)Ibuprofen anti-inflammatory inhibitor

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