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α-Vitamin E
🥰Excellent
Catalog No. T1648Cas No. 59-02-9
Alias Vitamin E, D-α-Tocopherol, Alpha-Tocopherol, 5,7,8-Trimethyltocol, (+)-alpha-Tocopherol
α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
α-Vitamin E
🥰Excellent
Purity: 99.89%
Catalog No. T1648Alias Vitamin E, D-α-Tocopherol, Alpha-Tocopherol, 5,7,8-Trimethyltocol, (+)-alpha-TocopherolCas No. 59-02-9
α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 mg | $38 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.89%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | α-Vitamin E (Dexrabeprazole Sodium) is a naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties. |
| Targets&IC50 | ERα (mouse):> 500 nM (EC50), Erythrocyte:3.658 μg/mL, J774 cells:> 500 μM, MCF7 cells:> 300 μM, THP-1 cells:> 500 μM, RPMI-8226 cells:> 300 μM, MT4 cells:165 μM, U-937 cells:100 μM, HepG2 cells:> 300 μM, HL-60 cells:255 μM |
| In vitro | vitamin E is capable of inducing necrosis in TC-1 cells and has antioxidant effects against nitric oxide[1]. |
| In vivo | Vitamin E induces TC-1 cell necrosis in vivo and reduces tumor volume in TC-1 tumor-bearing mice. Vitamin E reduces myeloid derived suppressor cells(MDSCs) in tumors of TC-1 tumor-bearing mice and enhances T cell accumulation[1]. |
| Cell Research | For in vitro cytotoxicity experiments, 1×105 TC-1 cells per well are added to 24-well plates. Eighteen hours later, tumor cells are treated with Vitamin E (0, 25, 50 μM). After 18 hours, apoptotic (Annexin V+ and 7AAD−) and necrotic (Annexin V+ and 7AAD+) cells are measured using PE Annexin V Apoptosis Detection Kit I. (Only for Reference) |
| Alias | Vitamin E, D-α-Tocopherol, Alpha-Tocopherol, 5,7,8-Trimethyltocol, (+)-alpha-Tocopherol |
| Molecular Weight | 430.71 |
| Formula | C29H50O2 |
| Cas No. | 59-02-9 |
| Smiles | CC1=C2C(CC[C@](CCC[C@@H](CCC[C@@H](CCCC(C)C)C)C)(C)O2)=C(C)C(O)=C1C |
| Relative Density. | 0.95g/mLat 25°C(lit.) |
Storage & Solubility Information
| Storage | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 12 mg/mL (27.86 mM), Sonication is recommended.  | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.2 mg/mL (2.79 mM), Solution. Saline: 25 mg/mL (58.04 mM), Solution. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Sci Citations
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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