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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
TQ0003 | 740 Y-P | 740YPDGFR,PDGFR 740Y-P | PI3K , Autophagy |
740 Y-P (740YPDGFR) is a potent and cell-permeable activator of PI3K. | |||
T13475 | β-Aminopropionitrile | 3-Aminopropionitrile,BAPN | Others , Endogenous Metabolite |
β-Aminopropionitrile (3-Aminopropionitrile) is a selective inhibitor of lysyl oxidase. | |||
T2503 | PAC-1 | Procaspase activating compound 1 | Apoptosis , Caspase , Autophagy |
PAC-1 (Procaspase activating compound 1) has been used in trials studying the treatment of Lymphoma, Melanoma, Solid Tumors, Breast Cancer, and Thoracic Cancers, among others. | |||
T1912 | Dinaciclib | SCH 727965,PS-095760 | Apoptosis , CDK |
Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 score = 3/1/1/4 nM). Dinaciclib has potential antitumor activity and inhibits the incorporation of thoracic glycan (dT... | |||
TN1724 | Harmalol hydrochloride | Harmidol hydrochloride | P450 , Antioxidant |
Harmalol hydrochloride (Harmidol hydrochloride) is a β-carboline alkaloid that can be extracted from the seeds of Peganum harmala L. Harmalol hydrochloride is the major metabolite of Harmaline and significantly inhibits ... | |||
TP2106L | Urantide acetate(669089-53-6 free base) | Neurotensin Receptor | |
Urantide acetate is a selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced ... | |||
T5S1889 | Yunaconitine | Guayewuanine B | Others |
1. Yunaconitine (Guayewuanine B) has anti-inflammatory and analgesic actions. 2. Yunaconitine was shown to have anti-thermic effect in pyrexial rats when administered orally at a dose of 5 μg/kg. 3. Yunaconitine shows po... | |||
T20692 | Schistoflrfamide | Pdvdhvflrfamide | |
Schistoflrfamide is a locust myosuppressin, it is isolated from the thoracic nervous system of the locust Schistocerca gregaria. | |||
T83596 | (+)-Osbeckic acid | ||
(+)-Osbeckic acid, extracted from Tartary Buckwheat, acts as a vasorelaxant and demonstrates a significant vasorelaxant effect in Sprague-Dawley rat thoracic aorta rings, with an EC50 value of 887 μM [1]. | |||
TN1246 | 3-Deoxysappanone B | Others | |
3-Deoxysappanone B has vasorelaxation effects, it can mediate endothelium- independent vasodilator action in rat thoracic aortic rings. | |||
TP2106 | Urantide | ||
Selective and competitive urotensin-II (UT) receptor antagonist (pKB = 8.3). Blocks hU-II induced contractions in thoracic aorta ex vivo. Exhibits no effect on noradrenaline or endothelin 1-induced contraction or on acet... | |||
T81782 | MLR12 | ||
mLR12 is a Trem1 inhibitory peptide that reduces the incidence of aortic rupture in a mouse model of BAPN-induced Thoracic Aortic Aneurysm and Dissection (TAAD) [1]. | |||
T76712 | Satralizumab | ||
Satralizumab, a humanized monoclonal antibody and potent Interleukin-6 (IL-6) inhibitor, prevents the formation and progression of descending thoracic aorta aneurysm (dTAA) in Rattus norvegicus. It is also used in resear... | |||
T35985 | CAY10487 | ||
The early stage of atherosclerosis is characterized by the aggregation of foam cells, so called a fatty streak, in the inner arterial wall. CAY10487 inhibits formation of fatty streak lesions of the thoracic aorta in hig... | |||
T36166 | 8-iso-15-keto Prostaglandin F2α | 8-iso-15-keto Prostaglandin F2α | |
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid pero... | |||
T38187 | 6-Aminophenanthridine | ||
6-Aminophenanthridine is an antiprion agent. It inhibits prion formation in yeast- and mammalian-based screening assays when used alone and, to a greater extent, when used in combination with the α2-adrenergic receptor a... | |||
T83910 | S1PL-IN-31 | Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31 | |
S1PL-IN-31 is a dual-function chemical compound acting as an inhibitor of sphingosine-1-phosphate (S1P) lyase with an IC50 value of 210 nM and as an antagonist of the Smoothened (Smo) receptor with an IC50 of 440 nM. Dem... |