Powder: -20°C for 3 years | In solvent: -80°C for 1 year
8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
100 μg | 35 days | $ 78.00 | |
500 μg | 35 days | $ 233.00 | |
1 mg | 35 days | $ 423.00 |
Description | 8-iso-15-keto Prostaglandin F2α (8-iso-15-keto PGF2α) is a metabolite of the isoprostane 8-iso PGF2α in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF2α) is a prostaglandin-like product of non-specific lipid peroxidation. In both humans and monkeys, exogenously infused 8-iso PGF2α is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation. A similar pattern is observed when tritiated 8-iso PGF2α is infused into rabbits. Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF2α was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF2α. 8-iso -15-keto PGF2α is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor. |
Synonyms | 8-iso-15-keto Prostaglandin F2α |
Molecular Weight | 352.471 |
Formula | C20H32O5 |
CAS No. | 191919-01-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PBS (pH 7.2): 1 mg/mL
Ethanol: 50 mg/mL
DMF: 50 mg/mL
DMSO: 50 mg/mL
You can also refer to dose conversion for different animals. More
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8-iso-15-keto Prostaglandin F2α 191919-01-4 8-iso-15-keto Prostaglandin F2a 8iso15keto Prostaglandin F2α 8-iso-15-keto Prostaglandin F-2α 8-iso-15-keto Prostaglandin F2alpha 8 iso 15 keto Prostaglandin F2α inhibitor inhibit