termination — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22285	Carboprost	15(S)-15-Methyl Prostaglandin F2α,15-Methyl-PGF2α	Prostaglandin Receptor
	Carboprost (15(S)-15-Methyl Prostaglandin F2α) is a synthetic prostaglandin analogue of PGF2α which has the effect of oxytocic. Carboprost is commonly used to restore uterine tone.		Prostaglandin Receptor
T31932	GJ071 oxalate	GJ 071,GJ-071,GJ071	Others
	GJ071 oxalate is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into na...		Others
T9117	BSJ-4-116		CDK , Ligand for E3 Ligase
	BSJ-4-116 is a highly potent and selective CDK12 degrader (PROTAC) with an IC50 of 6 nM. It downregulates DDR genes through a premature termination of transcription, primarily through increasing poly(adenylation).		CDK , Ligand for E3 Ligase
T1104	Paromomycin Sulfate	Aminosidine sulfate,Paromomycin sulfate salt	Antibacterial , Antibiotic , Parasite
	Paromomycin binds specifically to the RNA oligonucleotide at the A site of bacterial 30S ribosomes, thereby causing misreading and premature termination of translation of mRNA and inhibition of protein synthesis followed...		Antibacterial , Antibiotic , Parasite
T6446	Clevudine	L-FMAU,Levovir	HBV , DNA/RNA Synthesis
	Clevudine (Levovir) is a synthetic pyrimidine analogue with activity against hepatitis B virus (HBV). Intracellularly, clevudine is phosphorylated to its active metabolites, clevudine monophosphate and triphosphate. The ...		HBV , DNA/RNA Synthesis
T27108	Cymipristone	ZXH951,ZXH 951,ZXH-951
	Cymipristone, a progesterone receptor antagonist, is used potentially for termination of intrauterine pregnancy.
T61702	SRI-37240
	SRI-37240 is a powerful inhibitor of premature termination codons (PTCs). It effectively suppresses CFTR nonsense mutations and induces changes in cellular translation termination at PTCs in HEK293T cells. Additionally, ...
T33380	MI-389
	MI-389 is a protein degrader, targeting the translation termination factor G1 to S phase transition 1 (GSPT1).
T61306	SRI-41315
	SRI-41315, a chemical compound, effectively addresses premature termination codons (PTCs) associated with cystic fibrosis in immortalized and primary human bronchial epithelial cells. It induces a prolonged pause at stop...
T31933	GJ072	GJ-072,GJ 072
	GJ-072 is a Nonsense suppressor. Nonsense suppressors (NonSups) induce “readthrough”, i.e., the selection of near cognate tRNAs at premature termination codons and insertion of the corresponding amino acid into nascent p...
T34426	RTC14	Read-through compound-14,RTC 14,RTC-14,Read-through compound 14
	RTC14, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T34425	RTC13	Read-through compound 13,RTC 13,RTC-13
	RTC13, as a premature termination codon (PTC) readthrough inducer, can act by restoring dystrophin expression and improving muscle function in the mdx mouse model for Duchenne muscular dystrophy.
T11352	Galidesivir triphosphate	BCX4430-triphosphate,Immucillin-A triphosphate,BCX6870	Others
	Galidesivir triphosphate is a substrate for viral RNA-dependent RNA polymerase (RDRP), resulting in termination of viral RNA replication and thus serves as an antiviral. Galidesivir triphosphate inhibits HCV NS5B RNA pol...		Others
T41110	EFdA-TP
	EFdA-TP, a highly potent nucleoside reverse transcriptase (RT) inhibitor, exerts its inhibitory effect on RT-catalyzed DNA synthesis through both immediate and delayed chain termination mechanisms, commonly referred to a...
FL0097	Beta-L-D4A	2'3'-didehydro-2'3'-dideoxyadenosine
	beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. The biological activity of beta-L-D4A is connected with the termination of the DNA chain synthesis in the 5'-3' direction.
T83836	3'-O-Methylguanosine-5'-O-triphosphate sodium	3'-O-methyl GTP
	3'-O-Methylguanosine-5'-O-triphosphate (3'-O-methyl GTP), a methylated derivative of GTP, serves as a chain termination reagent in synthesizing early RNA polymerase II elongation intermediates.
T15378	Gemcitabine elaidate	Gemcitabine 5'-elaidate,Gemcitabine (elaidate),CO-101,CP-4126	Apoptosis , Nucleoside Antimetabolite/Analog , Autophagy
	Gemcitabine elaidate (CP-4126), is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracel...		Apoptosis , Nucleoside Antimetabolite/Analog , Autophagy
T36829	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
	9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the ...
T35802	ML-345
	Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. [1] In addition to regulating insulin a...
T60401	Tezacitabine
	Tezacitabine is a cytostatic and cytotoxic antimetabolite. Tezacitabine is a nucleoside analogue characterized by a dual mechanism of action. Tezacitabine irreversibly inhibits ribonucleotide reductase and can be incorpo...