subunit-selective — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T22748	DQP 1105		NMDAR
	DQP 1105 is a NMDA receptor antagonist.		NMDAR
T14971	CIQ		NMDAR
	CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.		NMDAR
T22192	BMS 195614	BMS614	Retinoid Receptor
	BMS 195614 (BMS614) is a selective RARα antagonist. BMS 195614 can bind to the RARα subunit.		Retinoid Receptor
T7870	TCN 201	TCN-201	NMDAR , iGluR
	TCN 201 is a selective antagonist of NMDA receptors containing the NR2A subunit.		NMDAR , iGluR
T5375	Loreclezole		GABA Receptor
	Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.		GABA Receptor
T12758	Ro 25-6981		NMDAR
	Ro 25-6981 is a potent and selective activity-dependent NMDA receptors blocker containing the NR2B subunit with IC50s of 0.009 and 52 μM for cloned receptor subunit combinations NR1C/NR2B and NR1C/NR2A respectively. Ro 2...		NMDAR
T21824	Sephin1	NSC 65390,IFB-088	Phosphatase
	Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α		Phosphatase
T9174	Icerguastat	Sephin 1,lcerguastat,IFB-088	Phosphatase
	Icerguastat (IFB-088) is a selective inhibitor of holophosphatase. Sephin1 safely and selectively inhibited a regulatory subunit of protein phosphatase 1 in vivo.		Phosphatase
T2067	NS11394	NS 11394	GABA Receptor
	NS11394 is a effective and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of α(5) > α(3) > α(2) > α(1) at GABA(A) alpha subunit-containing receptors.		GABA Receptor
T39217	PKA-IN-1		PKA
	PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study diseases of the immune system.		PKA
TP2063	α-Conotoxin MII		AChR
	α-Conotoxin MII is a highly potent and selective competitive antagonist for α3β2 subunit-containing nicotinic receptors (IC50 = 0.5 - 3.5 nM at α3β2 expressed in Xenopus oocytes). Also potently blocks β3-containing neuro...		AChR
T38272	Thiacloprid		AChR , Parasite
	Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 nM forDrosophilanAChRs and M10 mouse fibroblast cells expres...		AChR , Parasite
T73447	NP10679
	NP10679 is a selective, pH dependent GluN2B subunit -specific N-methyl-D-aspartate ( NMDA ) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC 50 s of 23 and 142...
T23457	Threo Ifenprodil hemitartrate		Others
	σ receptor agonist and NR2B subunit-selective NMDA receptor antagonist		Others
T30428	Besonprodil	Besonprodil (USAN),UNII-5K3N2D15WW,253450-09-8,CHEMBL219631,CI-1041
	Besonprodil is a drug that acts as an NMDA antagonist and is selective for the NR2B subunit.
T24717	Ro 25-6981 HCl	Ro 25 6981 HCl
	Ro 25-6981 HCl is an effective and selective NMDA glutamate receptors containing the NR2B subunit antagonist.
T16795	Rpn11-IN-1	Capzimin intermediate	Others
	Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).		Others
T24609	Thymidine 3',5'-disphosphate	Thymidine 3',5'-biphosphate,pdTp
	pdTp is a highly selective, small-molecule miRNA regulatory complex RISC subunit SND1 inhibitor.
TQ0233L	Traxoprodil Mesylate
	Traxoprodil Mesylate is a potent noncompetitive N-methyl-D-aspartate (NMDA) receptors antagonist and has selective for the NR2B subunit.
T70620	VU0466551
	VU0466551 is a selective activator of homomeric G protein gated, inwardly rectifying, potassium subunit 1 (GIRK1) channels.