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Loreclezole

Catalog No. T5375 CAS 117857-45-1

Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.

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Loreclezole, CAS 117857-45-1

Pack Size	Availability	Price/USD
1 mg	In Stock	48.00
5 mg	In Stock	102.00
10 mg	In Stock	154.00
25 mg	In Stock	335.00
50 mg	In Stock	618.00
100 mg	In stock	936.00
1 mL * 10 mM (in DMSO)	In Stock	117.00

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Purity 99.94%

HNMR HPLC COA

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Description	Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors.
Targets&IC50	GABAA
In vitro	Loreclezole, at concentrations above 6 microM, enhanced the degree and rate of apparent desensitization of the whole-cell current in a concentration-dependent manner [1]. The action of loreclezole depends on the type of beta subunit present in the receptor complex; receptors containing beta 2 or beta 3 subunits have > 300-fold higher affinity for loreclezole than receptors containing a beta 1 subunit [2].

Molecular Weight	274.53
Formula	C10H6Cl3N3
CAS No.	117857-45-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 90 mg/mL (327.83 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Donnelly JL, et al. Loreclezole enhances apparent desensitization of recombinant GABAA receptor currents. Neuropharmacology. 1996;35(9-10):1233-41. 2. Wingrove PB, et al. The modulatory action of loreclezole at the gamma-aminobutyric acid type A receptor is determined by a single amino acid in the beta 2 and beta 3 subunit. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4569-73.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Neuronal Signaling Compound Library Ion Channel Inhibitor Library GPCR Compound Library Neurotransmitter Receptor Compound Library Anti-Neurodegenerative Disease Compound Library Anti-Alzheimer's Disease Compound Library

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