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Metabolism Phosphatase Sephin1

Sephin1

Catalog No. T21824   CAS 13098-73-2
Synonyms: IFB-088, NSC 65390,

Sephin1 is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α

Sephin1, CAS 13098-73-2
Pack Size Availability Price/USD Quantity
25 mg In stock 74.00
50 mg In stock 112.00
100 mg In stock 168.00
200 mg In stock 252.00
1 mL * 10 mM (in DMSO) In stock 50.00
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Purity 99.80%
Biological Description
Chemical Properties
Storage & Solubility Information
Description Sephin1 is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α
In vitro Sephin1 leads to a strong attenuation of neuronal excitotoxicity independently of the integrated stress response[1].
In vivo Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis[2].
Synonyms IFB-088 , NSC 65390 ,
Purity 99.80%
Molecular Weight 196.64
Formula C8H9ClN4
CAS No. 13098-73-2

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

H2O: insoluble

DMSO: 7mg/ml(35.60mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature
1. Ruiz A , Zuazo J , Ortiz-Sanz C , et al. Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response[J]. International Journal of Molecular Sciences, 2020, 21(17):6088. 2. Das I , Krzyzosiak A , Schneider K , et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit[J]. Science, 2015, 348(6231):239-242.

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