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Sephin1

Catalog No. T21824 CAS 13098-73-2

Synonyms: NSC 65390, IFB-088

Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α

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Sephin1, CAS 13098-73-2

Pack Size	Availability	Price/USD
25 mg	In stock	$ 66.00
50 mg	In stock	$ 100.00
100 mg	In stock	$ 151.00
200 mg	In stock	$ 226.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.8%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sephin1 (IFB-088) is reportedly a selective inhibitor of GADD34 (PPP1R15A), which is a stress-induced regulatory subunit of protein phosphatase 1 complex that dephosphorylates eIF2α
In vitro	Sephin1 leads to a strong attenuation of neuronal excitotoxicity independently of the integrated stress response[1].
In vivo	Sephin1 safely prevented the motor, morphological, and molecular defects of two otherwise unrelated protein-misfolding diseases in mice, Charcot-Marie-Tooth 1B, and amyotrophic lateral sclerosis[2].

Synonyms	NSC 65390, IFB-088
Molecular Weight	196.64
Formula	C8H9ClN4
CAS No.	13098-73-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 7mg/ml(35.60mM)

H2O: insoluble

References and Literature

1. Ruiz A , Zuazo J , Ortiz-Sanz C , et al. Sephin1 Protects Neurons against Excitotoxicity Independently of the Integrated Stress Response[J]. International Journal of Molecular Sciences, 2020, 21(17):6088. 2. Das I , Krzyzosiak A , Schneider K , et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit[J]. Science, 2015, 348(6231):239-242.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library NO PAINS Compound Library Preclinical Compound Library Phosphatase Inhibitor Library ReFRAME Related Library Bioactive Compounds Library Max Glycometabolism Compound Library Bioactive Compound Library Metabolism Compound Library

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Vutiglabridin LMPTP INHIBITOR 1 dihydrochloride Sodium metatungstate D-ERYTHRO-SPHINGOSINE PTP1B/AKR1B1-IN-1 BCI-215 SHP099 TD52

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sephin1 13098-73-2 Metabolism Phosphatase Inhibitor protein misfolding diseases (E/Z)-Icerguastat PPP1R15A NSC 65390 NSC65390 PPP1R15B inhibit IFB 088 IFB088 (E/Z)-Sephin1 Sephin-1 IFB-088 NSC-65390 inhibitor

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