Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM). |
Targets&IC50 | RPN11:390 nM |
In vivo | Rpn11-IN-1 blocks the proliferation of tumor cells in culture. Rpn11 is a Zn2+-dependent metalloisopeptidase that hydrolyzes ubiquitin from tagged proteins that are trafficked to the proteasome for degradation. Rpn11-IN-1 has an IC50 of 2.1 μM and 3.8 μM against 293T and A549 cells, respectively. When inhibition of Rpn11-IN-1 against Rpn11 is measured in the presence of Zn(cyclen)2+ (100 μM), a significant loss in activity against Rpn11 is observed (IC50=77.4 μM vs. 0.39 μM). The observed IC50 value shift is attributed to the ability of Zn(cyclen)2+ to compete/titrate Rpn11-IN-1 away from Rpn11 [1]. |
Synonyms | Capzimin intermediate |
Molecular Weight | 315.41 |
Formula | C15H13N3OS2 |
CAS No. | 2084867-65-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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Rpn11-IN-1 2084867-65-0 Others Rpn11IN1 Rpn-11-IN-1 Rpn11 IN 1 Capzimin intermediate inhibitor inhibit