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Istaroxime hydrochloride

Catalog No. T15599 CAS 374559-48-5

Synonyms: PST2744 hydrochloride

Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.

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Istaroxime hydrochloride Chemical Structure

Istaroxime hydrochloride, CAS 374559-48-5

Pack Size	Availability	Price/USD
2 mg	5 days	$ 134.00
5 mg	5 days	$ 229.00
10 mg	5 days	$ 376.00
50 mg	6-8 weeks	$ 789.00
100 mg	6-8 weeks	$ 1,180.00
1 mL * 10 mM (in DMSO)	5 days	$ 252.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	Istaroxime hydrochloride is an inhibitor of Na+/K+-ATPase (IC50: 0.11 μM). It also is a sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (SERCA 2) activator.
Targets&IC50	Na+, K+-ATPase:0.11 μM
In vitro	Istaroxime (PST2744) inhibits the Na+/K+-ATPase activity from dog kidney (IC50: 0.43 ± 0.15 μM). Istaroxime hydrochloride acting as a positive inotropic compound through the inhibition of the Na+,K+-ATPase[2]. Inhibition of Na+/K+-ATPase activity in preparations from guinea pig kidney yielded potencies of 8.5 μM for PST2744[3].
In vivo	Istaroxime (PST2744) causes a progressive to enhance in +dP/dtmax throughout the infusion. That reaches 80% (ED80) at the cumulative dose of 1.89±0.37 mg/kg and a peak of 140±3.5% at the dose (EDmax) of 4.88±0.6 mg/kg[3].

Synonyms	PST2744 hydrochloride
Molecular Weight	396.96
Formula	C21H33ClN2O3
CAS No.	374559-48-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (113.36 mM)

References and Literature

1. Gobbini M, et al. Novel analogues of istaroxime, a potent inhibitor of Na+,K+-ATPase: synthesis and structure-activity relationship. J Med Chem. 2008 Aug 14;51(15):4601-8. 2. Gobbini M, et al. Novel analogues of Istaroxime, a potent inhibitor of Na(+),K(+)-ATPase: Synthesis, structure-activity relationship and 3D-quantitative structure-activity relationship of derivatives at position 6 on the androstane scaffold. Bioorg Med Ch 3. Micheletti R, et al. Pharmacological profile of the novel inotropic agent (E,Z)-3-((2-aminoethoxy)imino)androstane-6,17-dione hydrochloride (PST2744). J Pharmacol Exp Ther. 2002 Nov;303(2):592-600.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Istaroxime hydrochloride 374559-48-5 Others PST 2744 Hydrochloride PST-2744 Hydrochloride Istaroxime Hydrochloride PST2744 Hydrochloride PST2744 hydrochloride inhibitor inhibit

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