plasmodium — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN7103	13,21-Dihydroeurycomanone	Pasakbumin C	Anti-infection , Parasite
	13,21-Dihydroeurycomanone (Pasakbumin C) is a natural product isolated from the root of Eurycoma longifolia with antiparasitic activity such as Plasmodium falciparum and Toxoplasma gondii.		Anti-infection , Parasite
T6S0084	Tuberostemonine	Tuberstemonine	Parasite
	1. Tuberostemonine (Tuberstemonine) exhibits relatively higher intestinal permeabilities. 2. Tuberostemonine acts in part as an open-channel blocker at the crayfish neuromuscular junction.		Parasite
T1491	Atovaquone	Atavaquone	Others , P450 , Dehydrogenase , Antibiotic , Parasite
	Atovaquone (Atavaquone) is a hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.		Others , P450 , Dehydrogenase , Antibiotic , Parasite
T8767	PfDHODH-IN-2		Dehydrogenase , Parasite
	PfDHODH-IN-2 is a dihydrothiophenone derivative, is a potent Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH, IC50 : 1.11 μM) inhibitor . It is used an antimalarial agent and can be used for the research of m...		Dehydrogenase , Parasite
T12438	PfDHODH-IN-1		Dehydrogenase , Parasite
	PfDHODH-IN-1 is an analogue of the active Leflunomide metabolite, has antimalarial activity.		Dehydrogenase , Parasite
T12909	SID 26681509		Cysteine Protease , Parasite
	SID 26681509 is a selective, reversible and competitive human cathepsin L inhibitor (IC50 of 56 nM).		Cysteine Protease , Parasite
TN2027	Oxysanguinarine	8-Oxosanguinarine,Hydroxysanguinarine	Parasite
	Oxysanguinarine (Hydroxysanguinarine) possesses antiplatelet aggregation activity, it has potential inhibitory properties against the dengue virus.		Parasite
T5421	KDU691		Parasite , PI4K
	KDU691 is a PI4K inhibitor.		Parasite , PI4K
T16269	Nanaomycin A		DNA Methyltransferase , Dehydrogenase , Parasite
	Nanaomycin A, a quinone antibiotics, reactivates silenced tumor suppressor genes in human cancer cells. Nanaomycin A is a selective inhibitor of DNMT3B (IC50 = 500 nM).		DNA Methyltransferase , Dehydrogenase , Parasite
T10378	Artelinic acid		Others
	Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum.		Others
T67694	ZY-19489		Parasite
	ZY-19489 is an antimalarial compound that is a potential single-dose cure for Plasmodium falciparum and Plasmodium vivax malaria. It has received orphan drug designation from the FDA.		Parasite
T10356	AQ-13 dihydrochloride		Parasite
	AQ-13 dihydrochloride is an antimalarial drug. It is effective against drug-resistant strains of Plasmodium falciparum.		Parasite
T13246	UCT943		Parasite , PI4K
	UCT943 is an inhibitor of Plasmodium falciparum PI4K (IC50 = 23 nM).		Parasite , PI4K
T40417	Ethylhydrocupreine hydrochloride	Optochin hydrochloride	Antibacterial , Parasite
	Ethylhydrocupreine hydrochloride (Optochin hydrochloride) is a derivative of quinine with antimicrobial activity against Streptococcus pneumoniae.Ethylhydrocupreine hydrochloride has antimalarial activity with an IC50 of...		Antibacterial , Parasite
T11027	DHODH-IN-4		Dehydrogenase
	DHODH-IN-4 is a human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) inhibitor. The IC50 values of PfDHODH and HsDHODH are 4 μM and 0.18 μM, respectively. DHODH-IN-4 has antimalarial activity.		Dehydrogenase
T27400L	Ganaplacide phosphate	Ganaplacide phosphate (1261113-96-5 Free base)	Others
	Ganaplacide phosphate exerts multi-stage antimalarial activity against Plasmodium symptomatic asexual blood-stage infections, and is able to prevent transmission and block infection in animal models.		Others
T21022	Deacylketoconazole	Deacyl ketoconazole	Antifungal
	Deacylketoconazole (Deacyl ketoconazole) is a Ketoconazole derivative and is also an antifungal agent. Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole.		Antifungal
T16125	MMV390048		Parasite , PI4K
	MMV390048 is an antimalarial agent and is a representative of a new chemical class of Plasmodium PI4K inhibitor (Kdapp=0.3 μM). MMV390048 binds to the ATP binding site of Plasmodium PI4K and does not bind to other P. fal...		Parasite , PI4K
T3266	Lumefantrine	Benflumetol,dl-Benflumelol	Others , Parasite , Autophagy
	Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects again...		Others , Parasite , Autophagy
T3682	(-)-Catechin gallate	(-)-Catechin 3-O-gallate,(-)-Catechin 3-gallate	Others , COX
	(-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of 6PGD, IDH. (-)-Catechin gallate ((-)-Catechin 3-O-gallate) displays inhibition of human Beta-secretase. (-)-Catechin gallate ((-)-Catechin 3-O-gallat...		Others , COX