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Lumefantrine
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Catalog No. T3266Cas No. 82186-77-4
Alias dl-Benflumelol, Benflumetol
Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
Lumefantrine
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Purity: 98.36%
Catalog No. T3266Alias dl-Benflumelol, BenflumetolCas No. 82186-77-4
Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $53 | In Stock | In Stock | |
| 50 mg | $72 | In Stock | In Stock | |
| 100 mg | $101 | In Stock | In Stock | |
| 200 mg | $128 | In Stock | In Stock | |
| 500 mg | $198 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:98.36%
Appearance:Solid
Color:White
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Product Introduction
Lumefantrine AI Summary
Lumefantrine exhibits significant antimalarial activity against various strains of Plasmodium falciparum, including both multidrug-resistant and chloroquine-sensitive strains, with IC50 values in the low nanomolar range (ranging from 3.0 nM to 56.0 nM). It demonstrates effectiveness in inhibiting growth within human erythrocytes and shows promise in both laboratory assays and in vivo models, significantly reducing parasitemia and extending host survival in infected mice. Additionally, Lumefantrine exhibits activity against Plasmodium vivax with IC50 values between 14.6 nM to 37.6 nM. The compound also shows notable cytotoxicity against the human hepatocellular carcinoma cell line (Huh7) with a CC50 greater than 10000.0 nM, and it inhibits the IKr potassium channel with an IC50 value of approximately 8100 nM. Furthermore, it has demonstrated a variety of bioactivities, including antiviral properties against SARS-CoV-2 and chikungunya virus, as well as inhibition of human HDAC6 enzyme activity..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Lumefantrine (dl-Benflumelol) is an antimalarial agent used to treat acute uncomplicated malaria. It is administered in combination with artemether for improved efficacy. This combination therapy exerts its effects against the erythrocytic stages of Plasmodium spp. and may be used to treat infections caused by P. falciparum and unidentified Plasmodium species, including infections acquired in chloroquine-resistant areas. |
| Synonyms | dl-Benflumelol, Benflumetol |
| Molecular Weight | 528.94 |
| Formula | C30H32Cl3NO |
| Cas No. | 82186-77-4 |
| Smiles | C(CN(CCCC)CCCC)(O)C1=C2C(/C(=C\C3=CC=C(Cl)C=C3)/C=4C2=CC=C(Cl)C4)=CC(Cl)=C1 |
| Relative Density. | 1.252 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 5.29 mg/mL (10 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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