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Catalog No. T5421Cas No. 1513879-19-0
KDU691 is a PI4K inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePrice/USDAvailabilityQuantity
1 mg$54In Stock
2 mg$79In Stock
5 mg$121In Stock
10 mg$207In Stock
25 mg$441In Stock
50 mg$649In Stock
100 mg$926In Stock
1 mL x 10 mM (in DMSO)$133In Stock
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Product Introduction

KDU691 is a PI4K inhibitor.
In vivo
KDU691 was evaluated for in vivo activity in rhesus macaques infected with P. cynomolgi sporozoites.?The prophylactically treated monkeys failed to become blood smear positive, while untreated control animals showed normal parasitemia development (primary parasitemia at day 8.9 p.i., with the first relapse within a month).?Thus, 5-day oral treatment with 20 mg/kg of KDU691 shortly after infection eradicated all liver-stage parasites, including hypnozoites.
Animal Research
Sporozoites were harvested from P. cynomolgi-infected mosquitoes, washed with phosphate-buffered saline (PBS), and diluted to 100,000 sporozoites (spz)/ml in PBS. One-milliliter aliquots of sporozoites were prepared and injected into monkeys via intravenous injection. During treatment, monkeys were weighed daily and received the compound via gavage, followed by gastric feeding. Monkeys in the prophylaxis groups were treated 20 min after the i.v. sporozoite injection. The other monkeys were treated when all the monkeys in the experiment (except those in the prophylaxis group) were blood-stage patent (at day 11 p.i.). To kill the blood-stage parasites, all monkeys received a 5-day treatment of 7.5 mg/kg of body weight of chloroquine (CQ), during compound dosing. KDU691 was formulated in 0.5% methylcellulose and 0.5% Tween 80 in water. LMV599 was formulated as a solid dispersion in a solution containing 5.6% (wt/wt) Tween 80 44.4% hydroxypropyl methylcellulose (HPMC) E3 38.9% Soluplus 11.1% vitamin E d-alphatocopheryl polyethylene glycol 1000 succinate.
Chemical Properties
Molecular Weight419.86
Cas No.1513879-19-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 150 mg/mL (357.26 mM)
Solution Preparation Table
1 mM2.3817 mL11.9087 mL23.8175 mL119.0873 mL
5 mM0.4763 mL2.3817 mL4.7635 mL23.8175 mL
10 mM0.2382 mL1.1909 mL2.3817 mL11.9087 mL
20 mM0.1191 mL0.5954 mL1.1909 mL5.9544 mL
50 mM0.0476 mL0.2382 mL0.4763 mL2.3817 mL
100 mM0.0238 mL0.1191 mL0.2382 mL1.1909 mL


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Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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