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KDU691

Catalog No. T5421 CAS 1513879-19-0

KDU691 is a PI4K inhibitor.

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KDU691, CAS 1513879-19-0

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KDU691 is a PI4K inhibitor.
In vivo	KDU691 was evaluated for in vivo activity in rhesus macaques infected with P. cynomolgi sporozoites.?The prophylactically treated monkeys failed to become blood smear positive, while untreated control animals showed normal parasitemia development (primary parasitemia at day 8.9 p.i., with the first relapse within a month).?Thus, 5-day oral treatment with 20 mg/kg of KDU691 shortly after infection eradicated all liver-stage parasites, including hypnozoites.
Animal Research	Sporozoites were harvested from P. cynomolgi-infected mosquitoes, washed with phosphate-buffered saline (PBS), and diluted to 100,000 sporozoites (spz)/ml in PBS. One-milliliter aliquots of sporozoites were prepared and injected into monkeys via intravenous injection. During treatment, monkeys were weighed daily and received the compound via gavage, followed by gastric feeding. Monkeys in the prophylaxis groups were treated 20 min after the i.v. sporozoite injection. The other monkeys were treated when all the monkeys in the experiment (except those in the prophylaxis group) were blood-stage patent (at day 11 p.i.). To kill the blood-stage parasites, all monkeys received a 5-day treatment of 7.5 mg/kg of body weight of chloroquine (CQ), during compound dosing. KDU691 was formulated in 0.5% methylcellulose and 0.5% Tween 80 in water. LMV599 was formulated as a solid dispersion in a solution containing 5.6% (wt/wt) Tween 80 44.4% hydroxypropyl methylcellulose (HPMC) E3 38.9% Soluplus 11.1% vitamin E d-alphatocopheryl polyethylene glycol 1000 succinate.

Molecular Weight	419.87
Formula	C22H18ClN5O2
CAS No.	1513879-19-0

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 150 mg/mL (357.26 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Zeeman A M , Lakshminarayana S B , Werff N V D , et al. PI4 Kinase Is a Prophylactic but Not Radical Curative Target in Plasmodium vivax-Type Malaria Parasites[J]. Antimicrobial Agents & Chemotherapy, 2016, 60(5):AAC.03080-15.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Lung Cancer Compound Library HIF-1 Signaling Pathway Compound Library Glycometabolism Compound Library Anti-Cancer Metabolism Compound Library Anti-Obesity Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library

Related Products

Related compounds with same targets

Kuraridine Beta-mangostin Febrifugine TM2-115 Piperaquine β-Hederin Dehydroemetine Desethyl chloroquine

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

KDU691 1513879-19-0 PI3K/Akt/mTOR信号通路微生物学 Parasite PI4K PI4 kinases blood Inhibitor liver Phosphatidylinositol 4 kinases ring-stage falciparum plasmodium schizonts gametocytes KDU 691 KDU-691 inhibit stage inhibitor

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