nonpeptidic — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6485	Embelin	NSC 91874,Emberine,Embelic acid	Apoptosis , NF-κB , Lipoxygenase , IAP , Prostaglandin Receptor , Autophagy
	Embelin (Embelic acid), isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of apoptosis (IC50: 4.1 uM).
T3146	BMS-202	PD1-PDL1 inhibitor 2,PD-1/PD-L1 inhibitor 2	Apoptosis , PD-1/PD-L1
	BMS-202 (PD1-PDL1 inhibitor 2) is an inhibitor of the PD-1 (Programmed death- 1) /PD-Ll (Programmed death-ligand 1) protein/protein interaction.		Apoptosis , PD-1/PD-L1
T9292	ALE-0540	ALE0540	Others , Trk receptor
	ALE-0540 is a nonpeptidic heterocyclic molecule that inhibits the binding of NGF to p75 and TrkA, as well as signal transduction and biological responses mediated by TrkA receptors.		Others , Trk receptor
T4236	AR-M 1000390 hydrochloride	ARM390 Hydrochloride,ARM-390 HCl	Opioid Receptor
	AR-M 1000390 hydrochloride (ARM-390 HCl) , also known as ARM-390, is a low-internalizing nonpeptidic δ-selective opioid receptor agonist; derivative of SNC 80. Does not trigger acute desensitization of the analgesic resp...		Opioid Receptor
T26082	RID-F	Ridaifen-F,Ridaifen F
	RID-F is an inhibitor of the nonpeptidic proteasome.
T26439	A 74273	A-74273,A74273
	A 74273, a nonpeptidic and renin inhibitor, may be used to treat cardiovascular diseases due to renin inhibition.
T27661	JNJ-10329670
	JNJ 10329670 is a highly potent (Ki of approximately 30 nM), nonpeptidic, noncovalent inhibitor of human cathepsin S with immunosuppressive activity.
T33734	NS 11	NS-11,NS11
	NS 11 is an RGD-nonpeptidic mimetic.
T70946	SC 51316
	SC 51316 is a nonpeptidic angiotensin II (AII) receptor antagonist.
T12072	ML-00253764 hydrochloride		Others
	ML-00253764 hydrochloride is an antagonist of nonpeptidic melanocortin receptor 4 (MC4R) (Ki and IC50 of 0.16 µM and 0.103 µM, respectively).		Others
T69170	ATC0065 HCl
	ATC0065 dihydrochloride is a novel nonpeptidic and potent melanin-concentrating hormone receptor 1 (MCHR1) selective antagonist.
T16851	SB-267268		Others
	SB-267268 inhibits human and mouse αvβ3 (IC50s: 0.68 and 0.29 nM, respectively). SB-267268 is a selective and nonpeptidic alpha(v)beta3 and alpha(v)beta5 integrins antagonist (Kis: 0.9, 0.5 and 0.7 nM for human αvβ3, mon...		Others
T14781	Brilacidin	PMX 30063	Others
	Brilacidin is a nonpeptidic anti-infective in a new class of defensin mimetics used for the research of eye infections.		Others
T11630L	IFN alpha-IFNAR-IN-1		Others
	IFN alpha-IFNAR-IN-1 is a nonpeptidic, low-molecular-weight inhibitor of the interaction between IFN-α and IFNAR. It inhibits MVA-induced IFN-α responses by BM-pDCs (IC50: 2-8 μM).		Others
T11369	GB-110		Others
	GB-110 selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.		Others
T13846	PROTAC RIPK degrader-2		Others
	PROTAC RIPK degrader-2 is a nonpeptidic PROTAC ,and potently targets serine-threonine kinase RIPK2 and has highly selective for RIPK2 degradation.		Others
T11369L	GB-110 hydrochloride (1252806-70-4 free base)	GB-110 hydrochloride	Others
	GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR...		Others
T61210	R-PSOP
	R-PSOP is a potent and selective nonpeptidic NMUR2 antagonist, exhibiting binding affinity to human and rat NMUR2 with Ki values of 52 nM and 32 nM, respectively. This compound demonstrates moderate central nervous syste...
T73854	GB-110 hydrochloride
	GB-110 hydrochloride, a potent and orally active nonpeptidic agonist of the protease-activated receptor 2 (PAR2), selectively triggers PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM [1].
T79455	SARS-CoV-2 Mpro-IN-9		SARS-CoV
	SARS-CoV-2 Mpro-IN-9 (compound c7), a nonpeptidic, noncovalent inhibitor of SARS-CoV-2 main protease (Mpro), exhibits potent inhibitory action (IC50 = 0.085 μM) and improved physicochemical and drug metabolism and pharma...		SARS-CoV