Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist.
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5 mg | Inquiry | $ 311.00 | |
10 mg | Inquiry | $ 486.00 | |
25 mg | Inquiry | $ 873.00 | |
50 mg | Inquiry | $ 1,454.00 | |
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1 mL * 10 mM (in DMSO) | Inquiry | $ 441.00 |
Description | GB-110 hydrochloride selectively induces PAR2-mediated intracellular Ca2+ release in HT29 cells with an EC50 of 0.28 μM. GB-110 hydrochloride is a potent, orally active, and nonpeptidic protease activated receptor 2 (PAR2) agonist. |
In vitro | In an intracellular Ca2+ (iCa2+) mobilization assay using HT29 colon cancer cells, GB110 (EC50 240±20 nM; pEC50 6.7±0.05) is equipotent with the peptide agonist 2f-LIGRLO-NH2 (EC50 210±30 nM; pEC50 6.6±0.05), 10-fold more potent than SLIGRL-NH2, but ~35-fold less potent than trypsin (EC50 6±0.5 nM; pEC50 8.2±0.8). |
Synonyms | GB-110 hydrochloride |
Molecular Weight | 645.23 |
Formula | C33H49ClN6O5 |
CAS No. | T11369L |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 125 mg/mL (193.73 mM), Sonication is recommended.
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GB-110 hydrochloride (1252806-70-4 free base) T11369L Others 1252806-70-4 free base 1252806-70-4 GB-110 Hydrochloride GB 110 Hydrochloride GB 110 hydrochloride (1252806 70 4 free base) GB-110 hydrochloride GB110 Hydrochloride GB110 hydrochloride (1252806704 free base) inhibitor inhibit