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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T16162 | Mutated EGFR-IN-1 | Osimertinib analog | EGFR |
Mutated EGFR-IN-1 (Osimertinib analog) is a useful intermediate for the inhibitors design for mutated EGFR, such as L858R EGFR, Exonl9 deletion activating mutant, and T790M resistance mutant. | |||
T12130 | Mutated EGFR-IN-2 | EGFR | |
Mutated EGFR-IN-2 is an inhibitor of mutant-selective EGFR. | |||
T12131 | Mutated EGFR-IN-3 | EGFR | |
Mutated EGFR-IN-3 is a ATP-competitive and highly selective allosteric dibenzodiazepinone EGFR(L858R/T790M) and EGFR(L858R/T790M/C797S) inhibitor(IC50 of 12 nM and 13 nM, respectively. ) | |||
T3338 | Ceralasertib | AZD6738 | ATM/ATR |
Ceralasertib (AZD6738) is an orally active, and selective ATR kinase inhibitor with IC50 of 1 nM. | |||
T5175 | Azd1390 | ATM/ATR | |
AZD1390 is an exceptionally potent inhibitor of ATM in cells (IC50: 0.78 nM) with >10,000-fold selectivity over closely related members of the PIKK family of enzymes. | |||
T4443 | AZ32 | ATM/ATR | |
AZ32 is an orally bioavailable and blood-brain barrier-penetrating ATM inhibitor with an IC50 of <6.2 nM for ATM enzyme, and an IC50 of 0.31 μM for ATM in cell. | |||
T1958 | AZ20 | ATM/ATR , mTOR | |
AZ20 is an effective and specific inhibitor of ATR kinase (IC50: 5 nM, in a cell-free assay), 8-fold selectivity over mTOR. | |||
T6770 | AZD0156 | Apoptosis , ATM/ATR | |
AZD0156 , an effective and specific inhibitors of ATM kinase, is potential antineoplastic activities and chemo-/radio-sensitizing. | |||
T6734 | WZ8040 | EGFR | |
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor, does not inhibit ERBB2 phosphorylation (T798I). | |||
T1821 | CGK733 | CGK 733 | ATM/ATR |
CGK733 (CGK 733) is a potent and selective inhibitor of ATM/ATR. | |||
T3032 | VE-821 | ATR Inhibitor IV | ATM/ATR |
VE-821 (ATR Inhibitor IV) is a selective ATP competitive inhibitor of ATR( Ki/IC50: 13/26 nM in cell-free assays). | |||
T6261 | CP-466722 | CP 466722,CP466722 | ATM/ATR |
CP-466722, an effective and reversible ATM inhibitor, does not inhibit ATR and PI3K or PIKK family members in cells. | |||
T6612 | NU6027 | ATM/ATR , DNA-PK , CDK | |
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-aminopurine-based inhibitors. | |||
T2084 | ETP-46464 | ATM/ATR , DNA-PK , PI3K , mTOR | |
ETP-46464 is an effective and specific ATR inhibitor (IC50: 25 nM). | |||
TN1673 | Garcinone C | ATM/ATR , CDK , STAT , AChR , Antifection | |
Garcinone C is a xanthone derivative extracted from Garcinia oblongifolia Champ with anti-inflammatory, astringency, and granulation-promoting activities. Garcinone C is an AChE inhibitor and has potential cytotoxic effe... | |||
T7318 | Elimusertib | BAY-1895344 | ATM/ATR |
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... | |||
T2685 | KU-55933 | ATM Kinase Inhibitor | ATM/ATR , DNA-PK , PI3K , mTOR , Autophagy |
KU-55933 (ATM Kinase Inhibitor) is a potent and specific ATM inhibitor. | |||
T7122 | AZD-7648 | DNA-PK | |
AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity. | |||
T14511 | BAY1082439 | Apoptosis , PI3K | |
BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2]. Additionally, BAY1082439 is effective against mutated forms o... | |||
T3579 | PLX8394 | Raf | |
PLX8394 is an orally active inhibitor of serine/threonine-protein kinase B-Raf (BRAF) protein. PLX8394 can selectively bind to and inhibit the activity of both wild-type and mutated forms of BRAF, then inhibit the prolif... |