modulatory — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9148	KA2507		HDAC
	KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.		HDAC
T4S0554	Theaflavine-3,3'-digallate	TFBG,theaflavin digallate	Others
	1. Theaflavine-3,3'-digallate (theaflavin digallate) and lactic acid together could reduce herpes simplex virus transmission.		Others
T34114	Posatirelin	BRN 6006446,Posatirelinum,BRN-6006446,RGH-2202,BRN6006446	AChR
	Posatirelin (BRN6006446) is a synthetic peptide with modulatory activity and neurotrophic effects on monoaminergic and cholinergic systems for the study of vascular dementia.		AChR
T22711	DCB	3,3'-dichlorobenzaldazine	Others , GluR
	DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the positive allosteric regulation of mGluRs with the help of ...		Others , GluR
T12110	MRZ 2-514	8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one	NMDAR
	MRZ 2-514 (8-bromo-4,5-dihydroxypyridazino[4,5-b]quinolin-1-one) is a strychnine-insensitive modulatory site of the NMDA receptor (glycineB)antagonist with Ki of 33 μM.		NMDAR
TP2324	Thymulin		Immunology/Inflammation related
	Thymulin is a peptide hormone which is mainly produced by thymic epithelial cells and it has immune-modulatory and anti-inflammatory effects		Immunology/Inflammation related
T4808	Agmatine sulfate	Agmatine sulfate salt	Endogenous Metabolite , NO Synthase , Imidazoline Receptor
	Agmatine sulfate (Agmatine sulfate salt) is a bioactive metabolite of the arginine amino acid. It exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide sy...		Endogenous Metabolite , NO Synthase , Imidazoline Receptor
T15275	Fenobam		GluR
	Fenobam shows inverse agonist activity which blocks the mGlu5 receptor basal activity(IC50: 84 nM). Fenobam has anxiolytic activity. Fenobam is a selective and non-competitive mGluR5 antagonist acting at an allosteric mo...		GluR
T15286	Flindokalner	BMS-204352	Potassium Channel
	Flindokalner (BMS-204352) is a potassium channel modulator and a positive modulator of all neuronal Kv7 channel subtypes expressed in HEK293 cells. Flindokalner is a large conductance calcium-activated K channel (BKca) p...		Potassium Channel
T4752	1-Aminocyclopropane-1-carboxylic acid	1-Aminocyclopropanecarboxylic acid,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite , NMDAR
	1-Aminocyclopropane-1-carboxylic acid (ACC) is an intermediate in the synthesis of ethylene, the plant hormone responsible for biological processes ranging from seed germination to organ senescence. It is a small molecul...		Endogenous Metabolite , NMDAR
T25474	GW-Amide	Glycyl-tryptophanamide,GW Amide
	GW-Amide is a molluscan neuropeptide that exhibits potent modulatory effects on molluscan muscles.
T25453	Glaspimod	F 107647,SK&,F-107647,F107647
	Glaspimod is a synthetic hematoregulatory peptide. It shares biological and/or modulatory activities with natural hematopoetic cytokines.
T68612	DM175
	DM175 is a novel partial FXR agonist, causing specific modulatory effects on FXR activity that clearly differ from classical FXR agonists.
T12828	Salicortin		NF-κB , JNK
	Salicortin is a phenolic glycoside isolated from many plants such as Populus and Salix species, has anti-adipogenic, anti-amnesic, and immune-modulatory activity.		NF-κB , JNK
TN4112	Garciniaxanthone E		Others
	The synthetic caged Garcinia xanthone cluvenone induces cell stress and apoptosis and has immune modulatory activity.		Others
T15618	JNJ-46281222		GluR
	JNJ-46281222 is an metabotropic glutamate (mGlu) 2-selective, highly potent PAM (positive allosteric modulator). It has nanomolar affinity (Kd = 1.7 nM) and a high modulatory potency (pEC50 = 7.71).		GluR
T61322	KA2507 monohydrochloride
	KA2507 hydrochloride is a powerful and specific HDAC6 inhibitor, possessing an IC50 value of 2.5 nM. It displays no substantial toxicities while demonstrating significant antitumor efficacy and immune modulatory effects ...
T74747	Tamuzimod
	Tamuzimod, an effective immunomodulator, exhibits modulatory activity on S1P Receptors with EC50 values below 1 μM [1] [2].
T23808	BMS-986169
	BMS-986169 is a GluN2B Receptor Negative Allosteric Modulator. BMS-986169 showed a high binding affinity for the GluN2B subunit allosteric modulatory site (Ki: 4.03-6.3 nM) and selectively inhibited GluN2B receptor funct...
TN4725	Oxychelerythrine		Antifection
	Oxychelerythrine shows high modulatory activity enhancing the susceptibility of the S. aureus ATCC 6538 to all the tested antibiotics from two to four-fold. It also shows antifeeding activities against Tribolium castaneu...		Antifection