lysosomal — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T41160	Lalistat 2		Lipase
	Lalistat 2 is a selective inhibitor of lysosomal acid lipase with IC50 of 152 nM and exhibits no inhibition of human pancreatic lipase or bovine milk lipoprotein lipase (up to 10 μM).		Lipase
T5689	20-DEOXYINGENOL		Others , Autophagy
	20-DEOXYINGENOL is a natual product.		Others , Autophagy
T8678	Naphthazarin	5,8-Dihydroxy-1,4-naphthoquinone,DHNQ	Apoptosis
	Naphthazarin (5,8-Dihydroxy-1,4-naphthoquinone) is effective by various cellular mechanisms including oxidative stress, activation of mitochondrial apoptosis-inducing factor (AIF), depolymerization of microtubules, inter...		Apoptosis
T23004	ML-SA1	Mucolipin synthetic agonist 1	Others , TRP/TRPV Channel
	ML-SA1 (Mucolipin synthetic agonist 1) is a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV...		Others , TRP/TRPV Channel
T71126	Allixin
	Allixin is a phytoallexin found in garlic (Allium sativum) bulbs. Allixin has weak antimicrobial activity and exerts an anti-promoting activity against skin tumors induced by the chemical 12-O-tetradecanoylphorbol-13-ace...
T7944	VPS34 inhibitor 1 (Compound 19, PIK-III analogue)	PIK-III analogue	PI3K
	VPS34 inhibitor 1 (Compound 19, PIK-III analogue) (PIK-III analogue) is a potent and selective inhibitor of VPS34( IC50 : 15 nM)		PI3K
T40542	Sinbaglustat	ACT-519276,Sinbaglustat,OGT2378	Transferase
	Sinbaglustat (OGT2378) (OGT2378) is a dual inhibitor of glucose ceramide synthetase (GCS) and non-lysosomal glucose ceramidase (GBA2).Sinbaglustat is an orally administered N-alkyl iminosugar that crosses the blood-brain...		Transferase
T3436	LYS01	lys05 (free base)	Autophagy
	LYS01 free base is a new lysosomal autophagy inhibitor.		Autophagy
T21992	Vacuolin-1		PI3K , Autophagy
	Vacuolin-1 is a cell-permeable inhibitor of Ca2+ dependent fusion of lysosomes to the cell membrane. It acts by inhibiting release of lysosomal content.vacuolin‐1 is a potent and selective PIKfyve inhibitor and inhibits ...		PI3K , Autophagy
T37986	D-Mannose-6-Phosphate sodium salt hydrate		Others
	D-Mannose-6-Phosphate sodium salt hydrate is a multifunctional monosaccharide used in the study of metabolism, lysosomal delivery and cancer.		Others
T38344	Lalistat 1	ZINC795230	Antibacterial
	Lalistat 1 is an inhibitor of lysosomal acid lipase (LAL, IC50 = 68 nM) and IgA1 protease for H. influenzae. Lalistat 1 can be used in studies about niemann-pick type C diseases.		Antibacterial
T27730	KGP94	KGP-94,KGP 94	Cysteine Protease
	KGP94 is an inhibitor of cysteine protease Cathepsin L(CTSL).		Cysteine Protease
T5538	DC661		Apoptosis , Autophagy
	DC661 is a palmitoyl-protein thioesterase 1 (PPT1) inhibitor that acts as an anti-lysosomal agent by inhibiting autophagy, demonstrating anti-cancer activity.		Apoptosis , Autophagy
T6056	Thiamet G	TMG	Others , Autophagy
	Thiamet G is a potent, selective O-GlcNAcase inhibitor with Kiof 21 nM, while exhibiting 37, 000-fold selectivity over human lysosomal –hexosaminidase.		Others , Autophagy
T41308L	Gly-Phe β-naphthylamide acetate	Gly-Phe β-naphthylamide acetate(21438-66-4 Free base)	Others
	Gly-Phe β-naphthylamide acetate is the substrate of Cathepsin C and can be used for research on the function of cathepsin C, intralysosomal hydrolysis and lysosomal membrane permeability.		Others
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T11191	EN6		Proton pump , Autophagy
	EN6-mediated ATP6V1A modification decouples the v-ATPase from the Rags, leading to inhibition of mTORC1 signaling, increased lysosomal acidification and activation of autophagy. EN6 clears TDP-43 aggregates, a causative ...		Proton pump , Autophagy
T20626	Esomeprazole		Proton pump , Cysteine Protease
	Esomeprazole is the S-isomer of omeprazole, inhibits the lysosomal cysteine protease legumain to prevent cancer metastasis. Esomeprazole is a proton pump inhibitors (PPI).		Proton pump , Cysteine Protease
T3437	Lys05	Lys01 trihydrochloride	lysosomal autophagy , Autophagy
	Lys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compa...		lysosomal autophagy , Autophagy
T15635	JZP-430		Lipase , MAGL
	JZP-430 is an effective, highly selective, irreversible inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50: 44 nM). It also shows ~230-fold selectivity over fatty acid amide hydrolase (FAAH) and lysosomal acid lipase (LAL...		Lipase , MAGL