kappa-opioid — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6S1010	Allomatrine		Others
	Allomatrine is a natural product from Sophora alopecuroides L. Allomatrine, when given i.c.v., may stimulate the descending dynorphinergic neuron, resulting in the stimulation of KORs in the spinal cord.		Others
T11909	LY2444296	FP3FBZ	Opioid Receptor
	LY2444296 (FP3FBZ) is an orally active and selective antagonist of kappa opioid receptor(Ki = 1 nM).		Opioid Receptor
TQ0082	Aticaprant	LY-2456302,CERC-501	Opioid Receptor
	Aticaprant (LY-2456302) (CERC-501) is a potent and centrally-penetrant antagonist of the kappa-opioid receptor (Ki: 0.807 nM).		Opioid Receptor
T13414	ZT 52656A hydrochloride		Opioid Receptor
	ZT 52656A is a selective agonist of kappa opioid, and used for the prevention or alleviation of pain in the eye.		Opioid Receptor
TP2501	Difelikefalin acetate	Difelikefalin acetate(1024828-77-0 free base),CR 845 acetate,FE 202845 acetate	Opioid Receptor
	Difelikefalin acetate (CR 845 acetate) is a peripherally restricted kappa opioid receptor agonist. CR845 exhibit low P450 CYP inhibition and low penetration into the brain.		Opioid Receptor
T0102	Naloxone hydrochloride	Naloxone HCl	Opioid Receptor
	Naloxone hydrochloride (Naloxone HCl) is a specific opiate antagonist that has no agonist activity. It is a competitive antagonist at mu, delta, and kappa opioid receptors.		Opioid Receptor
T2870	Matrine	Vegard,Matridin-15-one,Matrinium,α-Matrine,(+)-Matrine	Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
	Matrine (Vegard), an alkaloid isolated from the Sophora genus, acts as a kappa opioid receptor agonist.		Mitophagy , Ferroptosis , Opioid Receptor , Autophagy
T1197	Trimebutine maleate	Debridat,Polibutin	Calcium Channel , Opioid Receptor
	Trimebutine maleate (Polibutin) is a weak mu-opioid agonist and has antimuscarinic effects. Trimebutine is an agonist of peripheral mu, delta, and kappa opiate receptors served as a spasmolytic drug for therapy of both c...		Calcium Channel , Opioid Receptor
T3417	Amentoflavone	Didemethyl-ginkgetin,Amenthoflavone,3',8''-Biapigenin	Apoptosis , P450 , Phospholipase , Reactive Oxygen Species , Opioid Receptor , COX , Antibacterial , RSV , Antifungal
	Amentoflavone (3',8''-Biapigenin), as a potent inhibitor of CYP3A4 and CYP2C9, can interact with many other medications. CYP3A4 and CYP2C9 are proteins used for drug metabolism in the body. Amentoflavone also is an inhib...
T34877	Tifluadom	KC-5103,KC5103,dl-Tifluadom,KC 5103
	Tifluadom is a type of kappa-opioid benzodiazepine.
T71019	Niravoline
	Niravoline is a kappa-opioid agonist.
T69886	FE-200041
	FE-200041 is a peripheral efficacious kappa opioid agonist.
T28094	MR2034
	MR2034 is an agonist of kappa-Opioid receptor. MR2034 stimulates hypothalamic-pituitary-adrenal axis.
T69818	GNTI TFA
	GNTI TFA is a selective kappa opioid receptor antagonist.
T24035	Eptazocine hydrobromide	MCV 4169,ST-2121,MCV-4169,sT 2121, l-,l-ST-2121
	Eptazocine hydrobromide is an agonist of the Opioid receptor and is a kappa-Opioid receptor agonist. It is also an Opioid analgesic and an Opioid receptor antagonist.
T27079	CR-665 Acetate	FE200665,CR-665,JNJ-38488502,CR665,FE-200665,JNJ38488502
	CR-665, a kappa-opioid agonist, is used potentially for the treatment of postoperative pain.
T73339	Anrikefon	HSK21542
	Anrikefon (HSK21542) is a kappa opioid receptor agonist with analgesic effect .
T69799	4-Me-PDTic
	4-Me-PDTic is a potent and selective kappa opioid receptor antagonist.
T71523	Norbinaltorphimine
	nor-Binaltorphimine dihydrochloride is a long-acting potent and highly selective kappa opioid receptor antagonist.
T25354	Dup 747	Dup-747,Dup747
	Dup 747 is an analgesic that binds with high affinity and selectivity to the kappa-opioid receptor.