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CR-665 Acetate

Catalog No. T27079 CAS 958873-83-1

Synonyms: JNJ-38488502, CR665, CR-665, JNJ38488502, FE-200665, FE200665

CR-665, a kappa-opioid agonist, is used potentially for the treatment of postoperative pain.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

CR-665 Acetate, CAS 958873-83-1

Pack Size	Availability	Price/USD
5 mg	6-8 weeks	Inquiry
50 mg	6-8 weeks	Inquiry
100 mg	6-8 weeks	Inquiry

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

CR-665, a kappa-opioid agonist, is used potentially for the treatment of postoperative pain.

Synonyms	JNJ-38488502, CR665, CR-665, JNJ38488502, FE-200665, FE200665
Molecular Weight	731.899
Formula	C38H53N9O6
CAS No.	958873-83-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Olesen AE, Kristensen K, Staahl C, Kell S, Wong GY, Arendt-Nielsen L, Drewes AM. A population pharmacokinetic and pharmacodynamic study of a peripheral κ-opioid receptor agonist CR665 and oxycodone. Clin Pharmacokinet. 2013 Feb;52(2):125-37. doi: 10.1007/s40262-012-0023-8. PubMed PMID: 23212610. 2. Arendt-Nielsen L, Olesen AE, Staahl C, Menzaghi F, Kell S, Wong GY, Drewes AM. Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxycodone in a multi-modal, multi-tissue experimental human pain model: selective effect on visceral pain. Anesthesiology. 2009 Sep;111(3):616-24. doi: 10.1097/ALN.0b013e3181af6356. PubMed PMID: 19672186. 3. Hughes FM Jr, Shaner BE, Brower JO, Woods RJ, Dix TA. Development of a Peptide-derived orally-active kappa-opioid receptor agonist targeting peripheral pain. Open Med Chem J. 2013 Nov 4;7:16-22. doi: 10.2174/1874104501307010016. PubMed PMID: 24222801; PubMed Central PMCID: PMC3821081. 4. Vanderah TW, Largent-Milnes T, Lai J, Porreca F, Houghten RA, Menzaghi F, Wisniewski K, Stalewski J, Sueiras-Diaz J, Galyean R, Schteingart C, Junien JL, Trojnar J, Rivière PJ. Novel D-amino acid tetrapeptides produce potent antinociception by selectively acting at peripheral kappa-opioid receptors. Eur J Pharmacol. 2008 Mar 31;583(1):62-72. doi: 10.1016/j.ejphar.2008.01.011. PubMed PMID: 18282565.

Dose Conversion

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CR-665 Acetate 958873-83-1 CR665 Acetate JNJ-38488502 CR665 CR 665 Acetate CR-665 JNJ38488502 FE-200665 FE200665 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.