cytoskeleton — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
TN1417	Azadirachtin		Apoptosis , Antifection
	Azadirachtin has antifungal activity, used as an insecticide.		Apoptosis , Antifection
T8473	MLS000532223		Rho , Ras
	MLS000532223 is a selectiveRho family GTPases inhibitor(EC50 : 16 μM to 120 μM).		Rho , Ras
T23372	SMIFH2		Others
	SMIFH2 is formin homology 2 (FH2) domains inhibitor.		Others
T2029	Bohemine		ERK , CDK
	Bohemine is a cyclin-dependent kinase inhibitor.		ERK , CDK
T10460	Batabulin	T138067	Apoptosis , Microtubule Associated
	Batabulin (T138067) is an antitumor compound, which binds covalently and selectively to a subset of the β-tubulin isotypes, thereby disrupting microtubule polymerization. Batabulin affects cell morphology and leads to ce...		Apoptosis , Microtubule Associated
T21785	AG957		Bcr-Abl
	Tyrphostin AG957, a tyrosine kinase inhibitor with anti-BCR/ABL tyrosine kinase activity restores beta1 integrin-mediated adhesion and inhibitory signaling in chronic myelogenous leukemia hematopoietic progenitors[1].		Bcr-Abl
T4451	Estramustine phosphate sodium	Ro 21-8837/001,Estramustine phosphate disodium	Apoptosis , Microtubule Associated
	Estramustine phosphate sodium (Ro 21-8837/001) is an antimicrotubule chemotherapy agent; arrests prostate cancer cells in the G2/M phase of the cell cycle.		Apoptosis , Microtubule Associated
T24494	MP265	MP-265,MP 265	Others
	MP265 disrupts the MreB cytoskeleton and has antiproliferative effects.		Others
T28001	MDK-6983	MDK-6983,Compound 6k,Autophagy inhibitor 6k,MDK6983	Autophagy
	MDK-6983 (MDK-6983) is an inhibitor of autophagy and disrupts the dynamics of actin cytoskeleton in human melanoma cells.		Autophagy
T20945	2,4-D	Hedonal,Macondray,2,4-D acid,Chloroxone	DNA/RNA Synthesis
	2,4-Dichlorophenoxyacetic acid (Hedonal) is a synthetic auxin used as a plant growth regulator and also used as a supplement in plant cell culture media. It is an active ingredient in herbicides used to disrupts the acti...		DNA/RNA Synthesis
T3580	FIPI	5-Fluoro-2-indolyl deschlorohalopemide	Phospholipase , Autophagy
	FIPI (5-Fluoro-2-indolyl deschlorohalopemide) is a derivative of halopemide which potently inhibits both PLD1 (IC50 = 25 nM) and PLD2 (IC50 = 20 nM); prevents PLD regulation of F-actin cytoskeleton reorganization, cell s...		Phospholipase , Autophagy
T3S1471	Cucurbitacin IIA	Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis , Survivin
	1. Cucurbitacin IIA (Dihydrocucurbitacin Q1) can induce apoptosis and enhance autophagy , contributes to the anti-inflammatory activity of Cucurbitacin IIA against inflammation-related diseases. 2. Cucurbitacin IIA is a ...		Apoptosis , Survivin
T5S1981	Alpha-Cyperone	(+)-α-Cyperone,α-Cyperone	Others , Endogenous Metabolite
	1. alpha-Cyperone (α-Cyperone) is a promising inhibitor of Hla production by S. aureus and protects lung cells from this bacterium. 2. alpha-Cyperone significantly inhibited PGE2 production by suppressing the LPS-induced...		Others , Endogenous Metabolite
T19512	Phalloidin		Others
	Phalloidin is a mushroom-derived toxin which used to label F-actin of the cytoskeleton with fluorochrome .		Others
T26075	Rhizopodin
	Rhizopodin is a potent natural macrolide antibiotic that effectively affects the actin cytoskeleton at nanomolar concentrations.
T28469	PT-262	PT 262
	PT-262 is a ROCK (Rho-associated coiled-coil forming protein kinase) inhibitor. It induces cytoskeleton remodeling and migration inhibition in lung carcinoma cells.
TP2249	Flutax 1		Others
	A fluorescent taxol derivative used for direct imaging of the microtubule cytoskeleton		Others
T24994	MreB Perturbing Compound A22 hydrochloride	A22 hydrochloride,MreB Perturbing Compound A22
	A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been proved to be an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permea...
T41196	Phalloidin-FITC
	Phalloidin-FITC is a green fluorescent cytoskeleton stain. Binds and labels F-actin. For most fluorescent imaging applications, cells should be fixed and permeablilized. Excitation/emission maxima λ ~496/516 nm.
T16387	Ombrabulin	AVE8062,AC7700	Microtubule Associated
	Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.		Microtubule Associated