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MreB Perturbing Compound A22 hydrochloride

Catalog No. T24994 CAS 22816-60-0

Synonyms: A22 hydrochloride, MreB Perturbing Compound A22

A22 is an inhibitor of MreB, an actin-like bacterial protein, and has been proved to be an antibiotic adjuvant. A22 inhibition of MreB disrupts the bacterial actin cytoskeleton, which can cause an increase in cell permeability and altered transport.

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MreB Perturbing Compound A22 hydrochloride Chemical Structure

MreB Perturbing Compound A22 hydrochloride, CAS 22816-60-0

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Synonyms	A22 hydrochloride, MreB Perturbing Compound A22
Molecular Weight	271.58
Formula	C8H9Cl3N2S
CAS No.	22816-60-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Bonez PC, Rossi GG, Bandeira JR, Ramos AP, Mizdal CR, Agertt VA, Dalla Nora ESS, de Souza ME, Dos Santos Alves CF, Dos Santos FS, Gündel A, de Almeida Vaucher R, Santos RCV, de Campos MMA. Anti-biofilm activity of A22 ((S-3,4-dichlorobenzyl) isothiourea hydrochloride) against Pseudomonas aeruginosa: Influence on biofilm formation, motility and bioadhesion. Microb Pathog. 2017 Oct;111:6-13. doi: 10.1016/j.micpath.2017.08.008. Epub 2017 Aug 10. PubMed PMID: 28804018. 2. Bonez PC, Ramos AP, Nascimento K, Copetti PM, Souza ME, Rossi GG, Agertt VA, Sagrillo MR, Santos RC, Campos MM. Antibacterial, cyto and genotoxic activities of A22 compound ((S-3, 4 -dichlorobenzyl) isothiourea hydrochloride). Microb Pathog. 2016 Oct;99:14-18. doi: 10.1016/j.micpath.2016.07.007. Epub 2016 Jul 16. PubMed PMID: 27427089. 3. Nicholson A, Perry JD, James AL, Stanforth SP, Carnell S, Wilkinson K, Anjam Khan CM, De Soyza A, Gould FK. In vitro activity of S-(3,4-dichlorobenzyl)isothiourea hydrochloride and novel structurally related compounds against multidrug-resistant bacteria, including Pseudomonas aeruginosa and Burkholderia cepacia complex. Int J Antimicrob Agents. 2012 Jan;39(1):27-32. doi: 10.1016/j.ijantimicag.2011.08.015. Epub 2011 Oct 10. PubMed PMID: 21993484.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

MreB Perturbing Compound A22 hydrochloride 22816-60-0 A22 Hydrochloride MreB Perturbing Compound A22 Hydrochloride A22 hydrochloride MreB Perturbing Compound A-22 hydrochloride A-22 Hydrochloride A 22 Hydrochloride MreB Perturbing Compound A22 inhibitor inhibit

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