cotransporter — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2010	S0859		Others
	S0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH.		Others
T38843	Enavogliflozin	DWP-16001	SGLT
	Enavogliflozin (DWP-16001) is an orally available small molecule and sodium glucose transporter 2 inhibitor.		SGLT
T17243	VU0463271	N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide	Potassium Channel
	VU0463271 (N-Cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM ...		Potassium Channel
TQ0011	PF-06869206		Sodium Channel
	PF-06869206 is an oral selective inhibitor of the sodium-phosphate cotransporter NaPi2a (SLC34A1, IC50: 380 nM).		Sodium Channel
T5444	CLP290	CLP-290	Potassium Channel
	CLP290 is an activator of the neuron-specific K+-Cl cotransporter KCC2 and displays potential for the treatment of a wide range of neurological and psychiatric indications.		Potassium Channel
TQ0139	VU 0240551	N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide,VU0240551-2-D4	Potassium Channel , Calcium Channel , HER
	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.		Potassium Channel , Calcium Channel , HER
T4999	Ertugliflozin	MK-8835,PF-04971729	SGLT
	PF-04971729 (Ertugliflozin (PF-04971729)) is a potent and selective inhibitor of the sodium-dependent glucose cotransporter 2 (SGLT2).		SGLT
T14984	CLP257		Potassium Channel
	CLP257 is a selective K+-Cl− cotransporter KCC2 activator (EC50: 616 nM) and it is inactive against NKCC1, GABAA receptors, KCC1, KCC3 or KCC4. CLP257 alleviates hypersensitivity in rats with neuropathic painc and it al...		Potassium Channel
T4564	Ethacrynic acid	Edecrin,Etacrynic Acid,Hydromedin	Others , Calcium Channel , NF-κB , GST
	Ethacrynic acid (Edecrin) is a nonsulfonamide loop diuretic that inhibits the activity of the Na+/K+/2Cl- cotransporter NKCC2 in the thick ascending limb of the loop of Henle. It also inhibits glutathione S-transferase a...		Others , Calcium Channel , NF-κB , GST
T35336	Furosemide sodium	Frusemide Sodium,Lasix	Na-K-Cl cotransporter
	Furosemide sodium (Frusemide Sodium) is a potent and orally active inhibitor of Na+/K+/2Cl- (NKCC) cotransporter, NKCC1 and NKCC2. Furosemide sodium is also a GABAA receptors antagonist and displays 100-fold selectivity ...		Na-K-Cl cotransporter
T11528	H100		Others
	H100 is a Cl- transport inhibitor, no effect against KCl cotransporter. It has partial effects against both the NaK2Cl cotransporter and the Band 3 anion exchanger.		Others
T16818	S-8921		Others
	S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.		Others
T17221	Velagliflozin		SGLT
	Velagliflozin is an orally available inhibitor of sodium-glucose cotransporter 2.		SGLT
T30534	BMS-639432
	BMS-639432 is a potent sodium-glucose cotransporter type II (SGLT2) inhibitor.
T15752	Licogliflozin	LIK066	SGLT
	Licogliflozin (LIK066) is an inhibitor of sodium-glucose cotransporter (SGLT1 and SGLT2).		SGLT
TN1842	Kushenol I		GABA Receptor , Antifection
	Kushenol I is a GABAA receptor modulator, it exhibits inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).Kushenol I is shown to be active against the plant pathogenic fungus Cladosporium cucumeri...		GABA Receptor , Antifection
T21399	Luseogliflozin	TS71,TS-071,TS 71,TS071,TS-71,TS 071
	Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM.
T28971	Tianagliflozin
	Tianagliflozin, a sodium/glucose cotransporter 2 (SGLT-2) inhibitor, is used potentially for the treatment of type 2 diabetes.
T15797	LX2761		Others
	LX2761 is a chemically stable and effective inhibitor against sodium-dependent glucose cotransporter 1 (SGLT1) and SGLT2 (IC50s: 2.2 nM and 2.7nM for hSGLT1 and hSGLT2). However, it shows specific SGLT1 inhibition in the...		Others
T12892	SGL5213		SGLT
	SGL5213 is an oral active and low-absorbable inhibitor of sodium-dependent glucose cotransporter 1 (SGLT1)(hSGLT1 and hSGLT2 with IC50 values of 29 nM and 20 nM , respectively),and has potential to treat type 2 diabetes.		SGLT