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Luseogliflozin

Catalog No. T21399 CAS 898537-18-3

Synonyms: TS71, TS-071, TS 71, TS071, TS-71, TS 071

Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM.

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Luseogliflozin, CAS 898537-18-3

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Luseogliflozin, a potent and competitive inhibitor of sodium-dependent glucose cotransporter 2 (SGLT2), competitively inhibits human SGLT2-mediated glucose uptake with a Ki value of 1.10 nM.

Synonyms	TS71, TS-071, TS 71, TS071, TS-71, TS 071
Molecular Weight	434.55
Formula	C23H30O6S
CAS No.	898537-18-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

H2O: Insoluble

References and Literature

1. Jinnouchi H, Nozaki K, Watase H, Omiya H, Sakai S, Samukawa Y. Impact of Reduced Renal Function on the Glucose-Lowering Effects of Luseogliflozin, a Selective SGLT2 Inhibitor, Assessed by Continuous Glucose Monitoring in Japanese Patients with Type 2 Diabetes Mellitus. Adv Ther. 2016 Feb 5. [Epub ahead of print] PubMed PMID: 26846284. 2. Haneda M, Seino Y, Inagaki N, Kaku K, Sasaki T, Fukatsu A, Kakiuchi H, Sato Y, Sakai S, Samukawa Y. Influence of Renal Function on the 52-Week Efficacy and Safety of the Sodium Glucose Cotransporter 2 Inhibitor Luseogliflozin in Japanese Patients with Type 2 Diabetes Mellitus. Clin Ther. 2016 Jan 1;38(1):66-88.e20. doi: 10.1016/j.clinthera.2015.10.025. Epub 2015 Dec 22. PubMed PMID: 26718606. 3. Nishimura R, Omiya H, Sugio K, Ubukata M, Sakai S, Samukawa Y. The sodium-glucose cotransporter 2 inhibitor luseogliflozin improves glycaemic control assessed by continuous glucose monitoring even on a low-carbohydrate diet. Diabetes Obes Metab. 2015 Dec 6. doi: 10.1111/dom.12611. [Epub ahead of print] PubMed PMID: 26639943. 4. Qiang S, Nakatsu Y, Seno Y, Fujishiro M, Sakoda H, Kushiyama A, Mori K, Matsunaga Y, Yamamotoya T, Kamata H, Asano T. Treatment with the SGLT2 inhibitor luseogliflozin improves nonalcoholic steatohepatitis in a rodent model with diabetes mellitus. Diabetol Metab Syndr. 2015 Nov 19;7:104. doi: 10.1186/s13098-015-0102-8. eCollection 2015. PubMed PMID: 26594248; PubMed Central PMCID: PMC4653899.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Luseogliflozin 898537-18-3 TS71 TS-071 TS 71 TS071 TS-71 TS 071 inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.