Powder: -20°C for 3 years | In solvent: -80°C for 1 year
S-8921 is an inhibitor of ileal Na+/bile acid cotransporter.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | S-8921 is an inhibitor of ileal Na+/bile acid cotransporter. |
In vitro | S-8921 inhibits the uptake velocity of 60 μM [3H] taurocholate dose-dependently in IBAT-COS cells (IC50 value of S-8921: 66±8 μM) [1]. |
In vivo | S-8921 treatment for 1 to 2 weeks induces a decrease in serum total cholesterol concentrations, with 0.01% S-8921 (4.0 to 4.6 mg/kg) being almost maximally effective. S-8921(Seven-day) treatment induces a dramatic decrease in serum cholesterol concentrations in hamsters. The hypocholesterolemic effects of S-8921 are dose-dependent, but S-8921 does not affect body weight. An increase of fecal bile acid excretion is observed especially at higher doses of S-8921 [1][2]. |
Molecular Weight | 540.6 |
Formula | C30H36O9 |
CAS No. | 151165-96-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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S-8921 151165-96-7 Others S 8921 S8921 inhibitor inhibit