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VU 0240551

Name: VU 0240551
Brand: TargetMol
SKU: TQ0139
Price: 31 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TQ0139Cas No. 893990-34-6

VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.

VU 0240551

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Purity: 99.9%

Catalog No. TQ0139Cas No. 893990-34-6

VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.

Pack Size	Price	Availability
1 mg	$31	In Stock
5 mg	$71	In Stock
10 mg	$127	In Stock
25 mg	$269	In Stock
50 mg	$463	In Stock
100 mg	$742	In Stock
200 mg	$987	In Stock
500 mg	$1,490	In Stock
1 mL x 10 mM (in DMSO)	$78	In Stock

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Purity:99.9%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
Targets&IC50	KCC2:560 nM
In vitro	VU 0240551 (0-100 μM) reduces the P cell response to GABA in a concentration-dependent manner and significantly reduces GABA-elicited hyperpolarization at doses of 75 and 100 μM[3].
In vivo	VU 0240551 (10 μM) significantly inhibits chloride influx in cells from euhydrated rats, but does not affect cells from salt-loaded rats[4].

Chemical Properties

Molecular Weight	342.44
Formula	C₁₆H₁₄N₄OS₂
Cas No.	893990-34-6
Smiles	S(CC(NC=1SC=C(C)N1)=O)C2=CC=C(N=N2)C3=CC=CC=C3
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: Insoluble

DMSO: 45 mg/mL (131.41 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9202 mL	14.6011 mL	29.2022 mL	146.0110 mL
5 mM	0.5840 mL	2.9202 mL	5.8404 mL	29.2022 mL
10 mM	0.2920 mL	1.4601 mL	2.9202 mL	14.6011 mL
20 mM	0.1460 mL	0.7301 mL	1.4601 mL	7.3005 mL
50 mM	0.0584 mL	0.2920 mL	0.5840 mL	2.9202 mL
100 mM	0.0292 mL	0.1460 mL	0.2920 mL	1.4601 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc