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VU 0240551

Catalog No. TQ0139 CAS 893990-34-6

VU 0240551 is a neuronal K-Cl cotransporter KCC2 inhibitor (IC50: 560 nM for K+ uptake assay in KCC2-overexpressing cells).

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VU 0240551, CAS 893990-34-6

Pack Size	Availability	Price/USD
5 mg	Inquiry	96.00
10 mg	Inquiry	140.00
50 mg	Inquiry	539.00
100 mg	Inquiry	700.00
200 mg	Inquiry	909.00
1 mL * 10 mM (in DMSO)	Inquiry	105.00

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Datasheet SDS

Biological Description

Chemical Properties

Storage & Solubility Information

Description	VU 0240551 is a neuronal K-Cl cotransporter KCC2 inhibitor (IC50: 560 nM for K+ uptake assay in KCC2-overexpressing cells).
In vitro	VU 0240551 exhibits selectivity over the Na-K-2Cl cotransporter, NKCCl. VU 0240551 also inhibits hERG and L-type Ca2+ channels [1].

Molecular Weight	342.44
Formula	C16H14N4OS2
CAS No.	893990-34-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 6 months

Solubility Information

DMSO: 50 mg/mL (146.01 mM)

Water: Insoluble

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Delpire E, et al. Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5383-8. 2. Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.