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VU 0240551

VU 0240551
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
Catalog No. TQ0139Cas No. 893990-34-6
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VU 0240551

Catalog No. TQ0139Cas No. 893990-34-6
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
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Pack SizePriceAvailabilityQuantity
5 mg$43In Stock
10 mg$76In Stock
25 mg$161In Stock
50 mg$278In Stock
100 mg$445In Stock
200 mg$592In Stock
1 mL x 10 mM (in DMSO)$47In Stock
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Product Introduction

Bioactivity
Description
VU 0240551 is a selective antagonist of neuronal K-Cl cotransporter KCC2 inhibitor with an IC50 of 560 nM. VU 0240551 inhibits L-type calcium channels and hERG.
Targets&IC50
KCC2:560 nM
In vitro
VU 0240551 (0-100 μM) reduces the P cell response to GABA in a concentration-dependent manner and significantly reduces GABA-elicited hyperpolarization at doses of 75 and 100 μM[3].
In vivo
VU 0240551 (10 μM) significantly inhibits chloride influx in cells from euhydrated rats, but does not affect cells from salt-loaded rats[4].
AliasN-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide, VU0240551-2-D4
Chemical Properties
Molecular Weight342.44
FormulaC16H14N4OS2
Cas No.893990-34-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: Insoluble
DMSO: 45 mg/mL (131.41 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9202 mL14.6011 mL29.2022 mL146.0110 mL
5 mM0.5840 mL2.9202 mL5.8404 mL29.2022 mL
10 mM0.2920 mL1.4601 mL2.9202 mL14.6011 mL
20 mM0.1460 mL0.7301 mL1.4601 mL7.3005 mL
50 mM0.0584 mL0.2920 mL0.5840 mL2.9202 mL
100 mM0.0292 mL0.1460 mL0.2920 mL1.4601 mL

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