c-met — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T9990	c-Met-IN-15		Antibacterial
	c-Met-IN-15 exhibits antibacterial activity.		Antibacterial
T10655	c-Met inhibitor 1		c-Met/HGFR
	c-Met inhibitor 1 is a c-Met receptor signaling pathway inhibitor, used for the treatment of cancer including glioblastoma, gastric, and pancreatic cancer.		c-Met/HGFR
T67859	C-Met inhibitor D9		c-Met/HGFR
	C-Met inhibitor D9 is a c-Met kinase inhibitor.		c-Met/HGFR
T10653	c-met-IN-1		c-Met/HGFR
	c-met-IN-1 is a potent and selective c-Met inhibitor (IC50: 1.1 nM) with antitumor activity.		c-Met/HGFR
T10654	c-Met-IN-2		c-Met/HGFR
	c-Met-IN-2 is a selective and orally available c-Met inhibitor (IC50: 0.6 nM) with antitumor activity.		c-Met/HGFR
T5349	SCR-1481B1	c-Met inhibitor 2	VEGFR , c-Met/HGFR
	SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitor		VEGFR , c-Met/HGFR
T7900	BAY-474		c-Met/HGFR
	BAY-474 is an inhibitor of tyrosine-protein kinase c-Met. It acts as an epigenetics probe		c-Met/HGFR
T2293	SGX-523		Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl
	SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.		Raf , p38 MAPK , c-Met/HGFR , Bcr-Abl
T6154	SU11274	Met Kinase Inhibitor,PKI-SU11274	Apoptosis , VEGFR , FGFR , c-Met/HGFR , CDK , Autophagy
	SU11274 (Met Kinase Inhibitor)(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.		Apoptosis , VEGFR , FGFR , c-Met/HGFR , CDK , Autophagy
T2680	NVP-BVU972		c-Met/HGFR
	NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.		c-Met/HGFR
T6095	JNJ-38877605		c-Met/HGFR
	JNJ-38877605 is an ATP-competitive c-Met inhibitor (IC50: 4 nM), 600-fold selective for c-Met than 200 other tyrosine and serine-threonine kinases.		c-Met/HGFR
T6094	MK-2461	MK2461	c-Met/HGFR
	MK-2461 is a novel inhibitor that targets multiple proteins and competitively binds to ATP sites, specifically inhibiting the activated c-Met protein with an average inhibitory concentration (IC50) of 2.5 nM.		c-Met/HGFR
T8409	SYN1143	RON-IN-1,AMG-1	c-Met/HGFR
	SYN1143 (AMG-1) is a potent inhibitor of human RON and c-Met.In vitro kinase assays showed that compound I is a potent inhibitor of human RON and c-Met with IC50s of 9 and 4 nmol/L, respectively.		c-Met/HGFR
T6378	AMG-458	AMG 458	c-Met/HGFR
	AMG-458 is a potent c-Met inhibitor with Ki of 1.2 nM, ~350-fold selectivity for c-Met than VEGFR2 in cells.		c-Met/HGFR
T37596	Terevalefim		c-Met/HGFR
	Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor.		c-Met/HGFR
T4332	c-Kit-IN-1	PDGFR inhibitor 1,DCC-2618	c-Met/HGFR , c-Kit
	c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM).		c-Met/HGFR , c-Kit
T9123	DS-1205		TAM Receptor
	DS-1205 is a potent and selective inhibitor of AXL kinase, with an IC50 of 1.3 nM. DS-1205 also inhibits MER, MET, and TRKA, with IC50s of 63, 104, and 407 nM, respectively. DS-1205 can inhibit cell migration in vitro an...		TAM Receptor
T6260	AMG-208	AMG 208	P450 , c-Met/HGFR
	AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.		P450 , c-Met/HGFR
T6117	Tivantinib	ARQ 197	Apoptosis , c-Met/HGFR
	Tivantinib (ARQ 197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity.		Apoptosis , c-Met/HGFR
T3274	S49076		FGFR , c-Met/HGFR , TAM Receptor
	S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.		FGFR , c-Met/HGFR , TAM Receptor