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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T4129 | Arachidonic acid | Immunocytophyte,arachidonate,Immunocytophyt,Vevodar | Others , Endogenous Metabolite |
Arachidonic acid (Immunocytophyte) is an unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is for... | |||
T14021 | 20-HETE | 20-hydroxy Arachidonic Acid | Others |
20-HETE (20-hydroxy Arachidonic Acid) is a CYP450 metabolite and a potent vasoconstrictor and it is an endogenous inhibitor of the large-conductance Ca2+-activated K+ channel in renal arterioles. 20-HETE increases NADPH ... | |||
T38070 | Arachidonic Acid-biotin | ||
Virtually all cellular arachidonic acid is esterified in membrane phospholipids where its presence is tightly regulated through multiple interconnected pathways. Free arachidonic acid is a transient, critical substrate f... | |||
T22581 | Arachidonic Acid Leelamide | Others | |
Arachidonic acid leelamide is a phospholipase A2 inhibitor. Phospholipase A is a hydrolase responsible for the release of arachidonic acid from the sn2 position of phospholipids. The released arachidonic acid is then con... | |||
T38067 | 5,6-dehydro Arachidonic Acid | ||
5,6-dehydro Arachidonic acid is an analog of arachidonic acid with an acetylene in the 5,6 position. It inhibits 5-LO in rat basophilic leukemia cells, with a Ki value of 15 μM. In guinea pig leukocytes, 5-LO is inhibite... | |||
T36232 | 20-carboxy Arachidonic Acid | ||
20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take p... | |||
T81609 | Omega-3 Arachidonic acid ethyl ester | (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester,ω-3 Arachidonic acid ethyl ester | |
Omega-3 Arachidonic Acid ethyl ester, a rare polyunsaturated fatty acid with limited presence in dietary sources, is crucial for infant growth and development and offers protection against heart disease, blood clots, hig... | |||
T21815 | ONO-RS-082 | Others | |
ONO-RS-082 is a Ca2+-independent phospholipase A2 inhibitor. | |||
T2367 | SKF-86002 | SKF86002 | p38 MAPK , TNF |
SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM). | |||
T0412 | Idebenone | CV-2619 | Apoptosis , Antioxidant , Mitochondrial Metabolism |
Idebenone (CV-2619) is a synthetic analogue of ubiquinone (Coenzyme Q10), a vital cell antioxidant and essential component of the Electron Transport Chain (ETC). | |||
T4P2931 | Linoleic acid | 9,12-octadecadienoic acid,acidelinoleique,9,12-Linoleic acid | Others , Endogenous Metabolite |
Linoleic acid (9,12-octadecadienoic acid) is an essential fatty acid. Prostaglandin precursor. | |||
T27026 | CJ-13,610 | CJ 13610,CJ-13610 | Lipoxygenase |
CJ-13,610 is an orally active and nonredox-type inhibitor of 5-lipoxygenase (5-LOX). CJ-13,610 inhibits the biosynthesis of leukotriene B4 and regulates the expression of IL-6 mRNA in macrophages. | |||
T62606 | ALOX15-IN-2 | Lipoxygenase | |
ALOX15-IN-2 is a potent inhibitor of ALOX15 linoleate oxygenase activity, inhibiting the oxidation of linoleic acid (LA) and arachidonic acid (AA), the immediate homologs of ALOX15, with IC50s of 1.55 and 2.79 μM, respec... | |||
T13632 | D-Erythro-dihydrosphingosine | Dihydrosphingosine,Octadecasphinganine,C18-Dihydrosphingosine,D-erythro-Sphinganine | Phospholipase , Endogenous Metabolite |
D-Erythro-dihydrosphingosine (C18-Dihydrosphingosine) inhibits arachidonic acid release and cPLA2α activity. | |||
TN1643 | Ferulamide | 4-Hydroxy-3-methoxycinnamide | PAFR , AChR |
Ferulamide (4-Hydroxy-3-methoxycinnamide), a Ferulic acid derivative, shows potent inhibitory activity against arachidonic acid-induced platelet aggregation. | |||
T70188 | ER-34122 | Lipoxygenase | |
ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor, exhibits potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model. | |||
T60061 | RU-TRAAK-2 | Potassium Channel | |
RU-TRAAK-2 is a reversible inhibitor of TWIK-related arachidonic acid-stimulated K+ channel with no activity for non-K2P channels including Kv1.2, GIRK2, and Slo1. | |||
T0961 | Trometamol | Tromethamine | COX |
Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostagland... | |||
T1420 | Diethylcarbamazine citrate | Caritrol,Loxuran,Dicarocide | Lipoxygenase , COX , Parasite |
Diethylcarbamazine citrate (Caritrol) is an anthelmintic used primarily as the citrate in the treatment of filariasis, particular infestations with Wucheria bancrofti or Loa loa. It is an inhibitor of arachidonic acid me... | |||
TN1873 | Lirinidine | Others | |
(+)-Lirinidine has antioxidative activity, and it can significantly inhibit the proliferation of melanoma cells; it also shows potent inhibition of melanogenesis. Lirinidine exhibits significant inhibition of collagen, a... |