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Linoleic acid

Name: Linoleic acid
Brand: TargetMol
SKU: T4P2931
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T4P2931Cas No. 60-33-3

Alias acidelinoleique, 9,12-octadecadienoic acid, 9,12-Linoleic acid

Linoleic acid (9,12-octadecadienoic acid) is a naturally occurring polyunsaturated fatty acid found in animal and vegetable oils. Linoleic acid is an essential fatty acid that is part of membrane phospholipids.

Linoleic acid

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Purity: 99.61%

Catalog No. T4P2931Alias acidelinoleique, 9,12-octadecadienoic acid, 9,12-Linoleic acidCas No. 60-33-3

Pack Size	Price	USA Warehouse	Global Warehouse
500 mg	$33	In Stock	In Stock
1 g	$46	In Stock	In Stock
2 g	$62	In Stock	In Stock
5 g	$88	-	In Stock
10 g	$128	-	In Stock
25 g	$215	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.61%

Appearance:Liquid

Color:Transparent

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COA

Product Introduction

Linoleic acid AI Summary

Linoleic acid demonstrates a broad spectrum of biological activities across various assays. It exhibits inhibitory effects on Bacillus subtilis spore germination at 2 x 10E-4 M concentration, with a 34.6% inhibition rate, and on rat liver microsomal Acyl coenzyme A:cholesterol acyltransferase with IC50 values exceeding 1,000,000 nM, indicating low potency. Linoleic acid affects the Torpedo nicotinic acetylcholine receptor, reducing amplitude to 72.0% at 0 minutes but increasing it to 175.0% at 10 minutes, suggesting a time-dependent transition from inhibition to stimulation. As an agonist at the GPR40 receptor, it enhances glucose-mediated insulin secretion in mouse MIN6 cells, with activity percentages of 172.0% and 141.0% at 30 uM for 25 mM and 5 mM glucose, respectively. This compound also shows antiviral activity against Hepatitis C virus, with an EC50 of 20200.0 nM, achieving 90.0% inhibition at 50 uM in 120 hours. It selectively inhibits COX2 (selectivity ratio of 0.6) and exhibits moderate potency in cholera toxin binding inhibition with an IC50 of 410,000.0 nM. Linoleic acid acts as agonist at PPARgamma, GPR40, and FFA4 receptors, demonstrating respective activities and binding affinities in the low micromolar range. It also inhibits FABP3 and FABP4, showing notable effects on their binding and displacement activities. In terms of enzyme inhibition, Linoleic acid shows activities against telomerase, soybean lipoxygenase 1, and AKR1C3 enzymes, amongst others. It possesses antioxidant properties and exhibits cytotoxicity against mouse RAW264.7 cells (LD50 > 10.0 uM) and multiple nematicidal activities. Additionally, it inhibits quorum-sensing in Vibrio harveyi and exhibits antinociceptive properties, further showcasing its potential in various biochemical and pharmacological applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Linoleic acid (9,12-octadecadienoic acid) is a naturally occurring polyunsaturated fatty acid found in animal and vegetable oils. Linoleic acid is an essential fatty acid that is part of membrane phospholipids.
Targets&IC50	CHO-K1 cells:0.54 μM (EC50), RBL-2H3 cells:> 50 μM, CHO cells:1.8 μM (EC50), HEK293 cells:4.8 μM (EC50)
In vitro	METHODS: Bovine satellite cell BSCs were treated with Linoleic acid (10-250 µM) for 24-48 h. Cell viability was measured by MTT assay. RESULTS: At 24 h of treatment with Linoleic acid, cell proliferation increased at doses of 10-100 µM and decreased at 250 µM as compared to untreated control. 100 µM Linoleic acid at 48 h had no significant effect on cell proliferation. [1] METHODS: Human ovarian cancer cells SKOV-3 were treated with Linoleic acid (16 µM) for 24 h. Cell migration was detected by wound-healing assay. RESULTS: The average migration in the Linoleic acid treated group increased by about 20% on average compared to control untreated cells. [2]
In vivo	METHODS: To study the effects on endocannabinoid (EC) biology, four groups of C57BL/6 mice were fed diets containing 1% or 8% Linoleic acid (with or without G (LAG)) for eight weeks. RESULTS: Increasing dietary Linoleic acid from 1% to 8% significantly increased circulatory, small intestinal, and hepatic ECS. 1% LAG-fed mice had the lowest feed efficiencies, and hepatic levels of only two ECs were reduced by the addition of G. [3]
Synonyms	acidelinoleique, 9,12-octadecadienoic acid, 9,12-Linoleic acid

Chemical Properties

Molecular Weight	280.45
Formula	C₁₈H₃₂O₂
Cas No.	60-33-3
Smiles	C(C/C=C\C/C=C\CCCCC)CCCCCC(O)=O
Relative Density.	0.902g/mLat 25°C(lit.)

Storage & Solubility Information

Storage

keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (196.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4.33 mg/mL (15.44 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.5657 mL	17.8285 mL	35.6570 mL	178.2849 mL
5 mM	0.7131 mL	3.5657 mL	7.1314 mL	35.6570 mL
10 mM	0.3566 mL	1.7828 mL	3.5657 mL	17.8285 mL
20 mM	0.1783 mL	0.8914 mL	1.7828 mL	8.9142 mL
50 mM	0.0713 mL	0.3566 mL	0.7131 mL	3.5657 mL
100 mM	0.0357 mL	0.1783 mL	0.3566 mL	1.7828 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc