adrenocortical — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T21865	BC 11-38		PDE
	BC 11-38 is a potent, selective PDE biodepressant which is mainly effective against PDE11 (IC50 : 0.28 μM).		PDE
T4277	Osilodrostat	LCI699	Glucocorticoid Receptor , Others , Hydroxylase
	Osilodrostat (LCI699) (LCI699) is an effective inhibitor of human 11β-hydroxylase (IC50: 2.5 nM) and aldosterone synthase (IC50: 0.7 nM).		Glucocorticoid Receptor , Others , Hydroxylase
T1199	Mitotane	Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD	Apoptosis , AChR
	Mitotane (NCI-C04933) is a derivative of the insecticide DICHLORODIPHENYLDICHLOROETHANE that specifically inhibits cells of the adrenal cortex and their production of hormones. It is used to treat adrenocortical tumors a...		Apoptosis , AChR
T12225L	Nevanimibe hydrochloride	PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis , Acyltransferase
	Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective inhibitor of acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) (EC50 of 9 nM).		Apoptosis , Acyltransferase
T20802	Flumethasone pivalate	Locacorten,NSC-107680,Lorinden,NSC 107680,NSC107680,Locorten	Others
	Flumethasone pivalate (Locorten) has antipruritic, anti-inflammatory, and vasoconstrictive properties and can be used in studies about adrenocortical suppression, cutaneous atrophy, plasma transcortin binding, and telang...		Others
T0948L	Corticosterone	17-Deoxycortisol,11β,21-Dihydroxyprogesterone,Kendall's compound B,Corticosterone (From plants)	Glucocorticoid Receptor , Endogenous Metabolite
	Corticosterone (Kendall's compound B) is an adrenocortical steroid with salocorticoid and glucocorticoid activity that is orally active. Corticosterone is involved in the regulation of energy, immune responses, and stres...		Glucocorticoid Receptor , Endogenous Metabolite
T2531L	Eprosartan	KF-108566J free base,Teveten	RAAS
	Eprosartan (SKF-108566J free base) is a selective and competitive nonpeptide angiotensin II receptor antagonist with high affinity for AT1 receptor subtypes and can be used as an antihypertensive agent.Eprosartan has an ...		RAAS
T8401	Efonidipine hydrochloride monoethanolate	NZ-105 hydrochloride monoethanolate	Calcium Channel
	Efonidipine hydrochloride monoethanolate (NZ-105 hydrochloride monoethanolate) is a Ca(2+)-channel Blocker, Enhances the Production of Dehydroepiandrosterone Sulfate in NCI-H295R Human Adrenocortical Carcinoma Cells		Calcium Channel
T3033	Deoxycorticosterone acetate	DOC acetate,Cortexone acetate,11-Deoxycorticosterone acetate	Glucocorticoid Receptor , Endogenous Metabolite , Adrenergic Receptor
	Deoxycorticosterone acetate (Cortexone acetate) is the 21-acetate derivative of desoxycorticosterone, used for intramuscular injection for replacement therapy of the adrenocortical steroid.
T1473	Trilostane	Win 24540	Dehydrogenase
	Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties. Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex.		Dehydrogenase
T19737	Perthane
	Perthane is the diethyl derivative of common pesticide DDD. It may cause adrenocortical atrophy in humans,and also prevent the formation of spontaneous mammary carcinoma.
T36472	Tetrahydro-11-deoxy Cortisol
	Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cyto...
T21074	Dexamethasone acetate	Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron
	Dexamethasone acetate is an adrenocortical steroid. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, asthma, severe allergies, chronic obstructive lung disease, bra...
T75135	FHD-609
	FHD-609, an inhibitor and degrader of BRD9 (bromodomain-containing protein 9), targets the ncBAF complex and is useful for researching a broad spectrum of cancers with mutations in a BAF complex subunit. When used alongs...
T35858	Adrenomedullin (22-52) (human) (trifluoroacetate salt)
	Adrenomedullin (22-52) is a C-terminal fragment of adrenomedullin (1-52) . In vitro, adrenomedullin (22-52) reduces basal corticosterone production in a mixture of rat adrenocortical and adrenomedulllary cells. It also r...
T72213	Efonidipine hydrochloride	NZ-105 hydrochloride
	Efonidipine HCl (NZ-105) serves as both a T-type and L-type calcium channel blocker. This compound, distinct from other calcium channel blockers, notably increases N(6), 2'-O-dibutyryladenosine 3',5'-cyclic monophosphate...