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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T26339L | XR-11576 HCl | XR-11576 HCl(346689-77-8 Free base) | Topoisomerase |
XR-11576 HCl is a novel orally active dual topoisomerase I and II inhibitor with antitumor activity. | |||
T35187 | XR 5944 | XR-5944,MLN-944,MLN944,XR5944,MLN 944 | |
XR 5944 is an effective DNA binder that stabilizes topoisomerase-dependent cleavage and has shown superior efficacy in a variety of mouse and human tumor models. | |||
T35188 | XR 808 | XR808,XR-808 | |
XR 808 is a biochemical. | |||
T35186 | XR 334 | XR-334,XR334 | |
XR 334 is a biochemical. | |||
T15143 | DMP-543 | XR-543 | Others , Potassium Channel |
DMP-543 (XR-543) is a potassium channel (KV7 channel) blocker that enhances the release of neurotransmitters. | |||
T26339 | XR-11576 | MLN-576,MLN 576,MLN576,XR 11576 | |
XR-11576 is a DNA topoisomerase I and II inhibitor for the treatment of solid tumors. | |||
T70417 | XR 1853 | ||
XR 1853 is a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. | |||
T29168 | XR-5000 | NSC-601316,CRC8805,SN-22995,DACA,CRC-8805 | |
XR-5000 is a DNA topoisomerase I and II inhibitor. | |||
T30356 | USAF XR-37 | Benzenecarboximidamide, 4,4'-iminobis-, dihydrochloride (9CI) | |
Benzenecarboximidamide, 4,4'-iminobis-, dihydrochloride (9CI) is a bioactive chemical. | |||
T21233 | Dihydrolipoic acid | Reduced thioctic acid,Reduced lipoic acid,DHLA,USAF XR-12,6,8-Dihydrothioctic acid | Antioxidant |
Dihydrolipoic acid (USAF XR-12), a dithiol-containing carboxylic acid, acts as a general antioxidant that is highly reactive against a variety of reactive oxygen species, including peroxynitirite, hydroxyl radicals, hydr... | |||
T125507 | Antibiotic XR 586 | ||
Antibiotic XR 586 is a useful organic compound for research related to life sciences. The catalog number is T125507 and the CAS number is 185981-24-2. | |||
T32397 | Kinoprene | XR 777,XR-777,XR777 | |
Kinoprene is a biochemical. | |||
T6287 | Tariquidar | XR9576 | P-gp |
Tariquidar (XR9576)(Kd=5.1 nM) is a specific and effective non-competitive inhibitor of P-glycoprotein. It can reverse drug resistance in MDR cell Lines. | |||
T6287L | Tariquidar dimesylate | D 06008,XR9576,D06008,XR 9576,Tariquidar dimesilate,XR-9576 | |
Tariquidar is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane t... | |||
T32758 | Linagliptin mixture with metformin | Jentadueto Xr,Linagliptin / metformin,Jentadueto | |
Linagliptin mixture with metformin is used for the treatment of type 2 diabetes. | |||
T32040 | Halauxifen | XDE 729,XDE729,DE-729,XDE-729,XR-729 | |
Halauxifen is a biochemical. | |||
T20028 | Janumet | Efficib,Janumet XR,Metformin / sitagliptin,Metformin hydrochloride mixture with sitagliptin phosphate | |
Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator. | |||
T27531 | Hedaquinium chloride | BIQ 16,Teoquil,B1Q 16,USAF XR-39,Teoquil chloride | |
Hedaquinium chloride has antibacterial activity. | |||
T68737 | XR9051 | ||
XR9051 is as a potent modulator of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR) following a synthetic chemistry programme based on a natural product lead compound. XR9051 was shown to be a potent inhibitor o... | |||
T29169 | XR9051 Hydrochloride | ||
XR9051 Hydrochloride, a potent modulator of P-glycoprotein-mediated multidrug resistance (MDR), inhibits the binding of cytotoxics to P-glycoprotein. | |||
T69618 | XR3054 | ||
XR3054 is a novel inhibitor of farnesyl protein transferase (FPTase). XR3054 inhibited the proliferation of the prostatic cancer cell lines LnCAP and PC3 and the colon carcinoma SW480 and HT1080 (IC50 values of 12.4, 12.... | |||
T72186 | Tariquidar dihydrochloride | XR9576 dihydrochloride | |
Tariquidar dihydrochloride, also known as XR9576 dihydrochloride, is a potent, specific P-glycoprotein (P-gp) inhibitor exhibiting high affinity (Kd = 5.1 nM). | |||
T69617 | ER-67880 | ||
ER-67880 is a novel and potent microtubule inhibitor with potential anticancer activity. | |||
T70416 | PD 154075 | ||
PD 154075 is a a non-peptide tachykinin NK1 receptor antagonist. | |||
T1783 | LXR-623 | LXR623,WAY 252623 | Liver X Receptor |
LXR-623 (WAY 252623) is an orally bioavailable and highly specifical synthetic modulator of LXR. | |||
T41255 | Specific PXR antagonist 70 | Others | |
Specific PXR antagonist 70 is a selective pregnane X receptor (PXR) antagonist with an IC50 of 540 nM and Ki of 390 nM for human PCR and enhances the chemosensitivity of cancer cells. | |||
T20759 | XRP44X | XRP-44-X,XRP 44X,XRP-44X,XRP 44 X | Ras |
XRP44X (XRP 44X) is a potent inhibitor of Ras-Net (Elk-3) pathway. | |||
T22305 | Dexrazoxane | ICRF-187 | Others |
Dexrazoxane (ICRF-187) is an anticancer drug used to block mitosis and arrest dividing cells. It is an iron chelator and provides cardioprotection against anthracycline toxicity. | |||
T13360 | XRK3F2 | Autophagy | |
XRK3F2 is an inhibitor of the p62-ZZ domain, blunts MM-induced Runx2 suppression in vitro, and induces new bone formation and remodeling in the presence of tumor in vivo. | |||
T29017 | TrxR1-IN-B19 | TrxR1INB19,Go Y015,TrxR1 IN B19,Go-Y015 | Others |
TrxR1-IN-B19 (TrxR1 IN B19), a TrxR1 inhibitor, selectively kills gastric cancer cells by a small molecule via targeting TrxR1 and ROS-mediated ER stress activation. | |||
T62021 | TrxR-IN-2 | ||
TrxR-IN-2 is a potential thioredoxin reductase (TrxR) inhibitor. TrxR-IN-2 has research value in the chemotherapy of drug-resistant hepatocellular carcinoma. | |||
T63415 | RXR antagonist 1 | ||
RXR antagonist 1 is a Retinoid X Receptor (RXR) modulator that exhibits high RXR antagonism (pA2: 8.06). RXR antagonist 1 can be used to study type 2 diabetes. | |||
T63989 | LXRβ agonist-3 | ||
LXRβ agonist-3 is a potent and selective LXRβ (liver X receptor β) agonist (EC50: 0.095 μM). LXRβ agonist-3 effectively inhibits U87EGFRvIII cells (IC50: 3.75 μM). . | |||
T72889 | FXR agonist 4 | ||
FXR agonist 4 with an EC 50 value of 1.05 μM. FXR agonist 4 effectively improves hyperlipidemia, hepatic steatosis, insulin resistance and hepatic inflammation in DIO mice. FXR agonist 4 can be used for the research of ... | |||
T41062 | HXR9 | ||
HXR9 is a cell-permeable peptide that acts as a competitive antagonist of the HOX/PBX interaction. It effectively inhibits the binding between HOX proteins and the transcription factor PBX, specifically in paralogue grou... | |||
T78781 | TrxR1-IN-1 | ||
Compound 5j, also known as TrxR1-IN-1, is a TrxR1 inhibitor with an IC50 of 8.8 μM. It exhibits anticancer activity, demonstrating IC50 values of 1.5 μM in MCF-7, 1.7 μM in HeLa, 2.4 μM in BGC-823, 2.8 μM in SW-480, and ... | |||
T60453 | TrxR-IN-3 | ||
TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and l... | |||
T74996 | FXR agonist 3 | ||
FXR agonist 3, an anti-NASH (Non-Alcoholic Steatohepatitis) agent, functions by activating FXR. It demonstrates anti-fibrogenic activity by inhibiting the expression of COL1A1, TGF-β1, α-SMA, and TIMP1. Additionally, it ... | |||
T62928 | XR8-69 | ||
XR8-69 is a SARS-CoV-2 PLpro inhibitor. XR8-69 has a low micromolar antiviral effect in SARS-CoV-2 infected human cells. | |||
T64148 | LXR agonist 2 | ||
LXR agonist 2 is a potent agonist of the LXR (liver X receptor). LXR agonist 2 stabilises NCOA1 (coactivator), which in turn agonises the LXR. | |||
T83128 | Aminooxy CatB-LXR | ||
Compound 10, Aminooxy CatB-LXR, constitutes an agent-linker conjugate for antibody-drug conjugates (ADC) [1]. | |||
T64171 | LXR antagonist 2 | ||
LXR antagonist 2 (compound 10rr) is a potent LXR (liver X receptor) inverse agonist, acting on LXRβ (IC50: 0.36 μM) and LXRα (IC50: 2.25 μM). LXR antagonist 2 is an adipogenesis inhibitor that downregulates LXR target ge... | |||
T63597 | RXR antagonist 2 | ||
RXR antagonist 2 is a potent antagonist of RXR (Ki: 0.391 μM, Kd: 0.281 μM). RXR antagonist 2 has shown research potential for RXR-related diseases. | |||
T63723 | LXR agonist 1 | ||
LXR (Liver X receptor) agonist 1 is a potent agonist of LXR, capable of acting on LXR-α (AC50: 1.5 nM) and LXR-β (AC50: 12 nM). LXR agonist 1 has shown research potential in atherosclerosis. | |||
T35189 | XRD 489 | XRD489,XRD-489,D 489 | |
XRD 489 is a biochemical. | |||
T83885 | DXR Inhibitor 11a sodium | 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitor 11a | |
DXR inhibitor 11a, with an IC50 value of 0.11 µM, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also demonstrates significant activity against P. falciparum's growth in isol... | |||
T83908 | DXR Inhibitor 11a (free acid) | 1-Deoxy-D-Xylulose-5-phosphate Reductoisomerase Inhibitor 11a | |
DXR inhibitor 11a, with an IC50 of 0.11 µM, effectively inhibits P. falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (DXR). It also hampers the growth of P. falciparum in isolated human erythrocytes, demonstrat... | |||
T61647 | TrxR-IN-5 | ||
TrxR-IN-5 (compound 4f) is an efficacious inhibitor of TrxR (thioredoxin reductase) with an IC50 of 0.16 μM. By elevating the levels of reactive oxygen species (ROS), TrxR-IN-5 fosters robust antiproliferative impacts. A... | |||
T64144 | FXR antagonist 1 | ||
FXR antagonist 1 is a selective, orally active intestinal FXR antagonist with an IC50 value of 2.1 μM. FXR antagonist 1 antagonises intestinal FXR and selectively inhibits intestinal FXR signalling by feedback activation... | |||
T11899 | LXRβ agonist-2 | Others | |
LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM. |
Cat No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-03460 | DCXR Protein, Human, Recombinant (His) | Human | E. coli |
DCXR, also known as HCR2, belongs to the short-chain dehydrogenases/reductases (SDR) family. It is highly expressed in kidney, liver and epididymis. In the epididymis, DCXR is mainly expressed in the proximal and dist... | |||
TMPK-01331 | TSLPR Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 Cells |
Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of t... | |||
TMPJ-00530 | TSLPR Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
TSLPR Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 62-88 KDa and the accession number is AAH23788.1. | |||
TMPJ-00531 | TSLPR Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
TSLPR Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-40 KDa and the accession number is AAH23788.1. | |||
TMPY-02953 | TEM8/ANTXR1 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are ser... | |||
TMPK-01151 | MXRA8 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Human, Recombinant (His) is expressed in ... | |||
TMPY-00380 | ANTXR2 Protein, Human, Recombinant (hFc) | Human | HEK293 Cells |
ANTXR2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.4 kDa and the accession number is P58335-4. | |||
TMPH-02314 | XRCC5 Protein, Human, Recombinant (His & MBP) | Human | Baculovirus Insect Cells |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPY-04094 | ANTXR2 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
ANTXR2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 32.3 kDa and the accession number is Q3TCL6. | |||
TMPJ-01333 | TEM8/ANTXR1 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
Anthrax Toxin Receptor 1 (ANTXR1) is a single-pass type I membrane protein that belongs to the ATR family. ANTXR1 contains one VWFA domain and binds PA through the VWA domain. ANTXR1 is highly expressed in tumor endothel... | |||
TMPH-02512 | TEM8/ANTXR1 Protein, Mouse, Recombinant (His) | Mouse | E. coli |
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskel... | |||
TMPY-02271 | TRXR1/TXNRD1 Protein, Human, Recombinant (aa 161-647, His) | Human | E. coli |
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidat... | |||
TMPK-00702 | ANTXR2 Protein, Human, Recombinant (His) | Human | HEK293 Cells |
The Capillary Morphogenesis Gene 2 (CMG2) gene encodes an Anthrax toxin receptor (ANTXR2),ANTXR2/CMG2 was originally identified as a result of up-regulation during capillary morphogenesis of endothelial cells (ECs) cultu... | |||
TMPY-05000 | NPTXR Protein, Human, Recombinant (His) | Human | HEK293 Cells |
NPTXR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 52.8 kDa and the accession number is O95502. | |||
TMPH-02686 | GLXR Protein, Mouse, Recombinant (His & SUMO) | Mouse | E. coli |
Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate. | |||
TMPH-03167 | ToxR Protein, Pseudomonas aeruginosa, Recombinant (His) | Pseudomonas aeruginosa | E. coli |
Positive regulation of toxA gene transcription. toxR Protein, Pseudomonas aeruginosa, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 32.9 kDa and the acces... | |||
TMPH-01355 | FXR1 Protein, Human, Recombinant (His) | Human | E. coli |
RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. FXR1 Protein, Human, Recombinant (His) is expressed in E... | |||
TMPH-01747 | FDXR Protein, Human, Recombinant (His & SUMO) | Human | E. coli |
Serves as the first electron transfer protein in all the mitochondrial P450 systems including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitam... | |||
TMPH-02315 | XRCC5 Protein, Human, Recombinant (His & Myc) | Human | E. coli |
Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a... | |||
TMPY-00615 | ANTXR2 Protein, Mouse, Recombinant (hFc) | Mouse | HEK293 Cells |
ANTXR2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 57.9 kDa and the accession number is Q3TCL6. | |||
TMPH-02513 | TEM8/ANTXR1 Protein, Mouse, Recombinant (His & Myc) | Mouse | HEK293 Cells |
Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskel... | |||
TMPK-01166 | MXRA8 Protein, Mouse, Recombinant (His) | Mouse | HEK293 Cells |
Mxra8 is a recently described receptor for multiple alphaviruses, including Chikungunya (CHIKV), Mayaro (MAYV), Ross River (RRV), and O'nyong nyong (ONNV) viruses. MXRA8 Protein, Mouse, Recombinant (His) is expressed in ... | |||
TMPH-01819 | LXR-alpha Protein, Human, Recombinant (His & Myc) | Human | E. coli |
LXR-alpha Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 53.1 kDa and the accession number is Q13133. | |||
TMPH-02807 | NPTXR Protein, Mouse, Recombinant (His & Myc) | Mouse | Baculovirus Insect Cells |
May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. |