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Janumet

Catalog No. T20028 CAS 1011232-08-8

Synonyms: Efficib, Janumet XR, Metformin / sitagliptin, Metformin hydrochloride mixture with sitagliptin phosphate

Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Janumet, CAS 1011232-08-8

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Biological Description

Chemical Properties

Storage & Solubility Information

Description

Metformin hydrochloride mixture with sitagliptin phosphate is an AMP-activated protein kinase stimulant. It is also a CD26 antigen inhibitor, Gluconeogenesis inhibitor, and Glucose modulator.

Synonyms	Efficib, Janumet XR, Metformin / sitagliptin, Metformin hydrochloride mixture with sitagliptin phosphate
Molecular Weight	670.93
Formula	C20H30ClF6N10O5P
CAS No.	1011232-08-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: Soluble

References and Literature

1. El-Zaher AA, Elkady EF, Elwy HM, Saleh MAEM. A Versatile Liquid Chromatographic Method for the Simultaneous Determination of Metformin, Sitagliptin, Simvastatin, and Ezetimibe in Different Dosage Forms. J AOAC Int. 2018 Mar 1;101(2):401-409. doi: 10.5740/jaoacint.17-0050. Epub 2017 Jul 27. PubMed PMID: 28748781. 2. Lotfy HM, Mohamed D, Mowaka S. A comparative study of smart spectrophotometric methods for simultaneous determination of sitagliptin phosphate and metformin hydrochloride in their binary mixture. Spectrochim Acta A Mol Biomol Spectrosc. 2015;149:441-51. doi: 10.1016/j.saa.2015.04.076. Epub 2015 Apr 30. PubMed PMID: 25978011. 3. El-Bagary RI, Elkady EF, Ayoub BM. Liquid chromatographic determination of sitagliptin either alone or in ternary mixture with metformin and sitagliptin degradation product. Talanta. 2011 Jul 15;85(1):673-80. doi: 10.1016/j.talanta.2011.04.051. Epub 2011 Apr 27. PubMed PMID: 21645757. 4. El-Bagary RI, Elkady EF, Ayoub BM. Spectroflourometric and spectrophotometric methods for the determination of sitagliptin in binary mixture with metformin and ternary mixture with metformin and sitagliptin alkaline degradation product. Int J Biomed Sci. 2011 Mar;7(1):62-9. PubMed PMID: 23675222; PubMed Central PMCID: PMC3614813.

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Janumet 1011232-08-8 Efficib Janumet XR Metformin / sitagliptin Metformin hydrochloride mixture with sitagliptin phosphate inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.