th17 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T7388	GSK805		ROR
	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi...		ROR
T6668	SGC-CBP30		Epigenetic Reader Domain , Histone Acetyltransferase
	SGC-CBP30 is an effective CREBBP/EP300 inhibitor (IC50: 21/38 nM).		Epigenetic Reader Domain , Histone Acetyltransferase
T14369	AZD-0284		ROR
	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].		ROR
T3100	GSK-J4	GSK J4 HCl	Apoptosis , Histone Demethylase
	GSK-J4 (GSK J4 HCl) is a potent H3K27me3 demethylase inhibitor, with IC50s of 8.6 μM and 6.6 μM towards KDM6B and KDM6A respectively. It is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX wit...		Apoptosis , Histone Demethylase
T9195	SHR0302	ARQ252	Apoptosis , JAK
	SHR0302 (ARQ252) is a JAK inhibitor that binds JAK1 with stronger affinity than others (Selectivity for JAK1 is more than 10 times for JAK2, 77 times for JAK3, 420 times for Tyk2).		Apoptosis , JAK
T13502	3-Oxo-5β-cholanoic acid	Dehydrolithocholic acid	ROR
	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM)...		ROR
T4383	GSK-J4 Hydrochloride	GSK J4 HCl,GSK J4 HCl (1373423-53-0 free base)	Histone Demethylase
	GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.		Histone Demethylase
T67864	TH1760	MKB	NUDIX hydrolase
	TH1760 (MKB) is an inhibitor of NUDIX-type 15 (NUDT15, IC50= 25 nM). TH1760 can sensitize cells to 6-thioguanine by increasing the accumulation of 6-thio- (d) GTP in nucleic acids. TH1760 can enhance the anti-leukemia ef...		NUDIX hydrolase
T12753	RORγt Inverse agonist 6		ROR
	RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.		ROR
T76884	Spesolimab	BI 655130	IL Receptor
	Spesolimab (BI 655130) is an anti-interleukin-36 receptor antibody. IL-36 plays an important role in the immune system and is associated with a reduction in biomarkers associated with congenital Th1/Th17 and neutrophil p...		IL Receptor
T37587	ML 209		ROR
	ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM...		ROR
T19710	Ciglitazone	Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis , p38 MAPK , PPAR
	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelia...		Apoptosis , p38 MAPK , PPAR
T12112	MS402		Epigenetic Reader Domain
	MS402 is a novel BD1-selective BET BrD inhibitor.		Epigenetic Reader Domain
T27279	ER819762	ER-819762,ER 819762
	ER819762, an antagonist of the prostaglandin E2 EP4 receptor, inhibits Th1 differentiation and Th17 expansion.
T19590	Trehalose 6-behenate		Others
	Trehalose 6-behenate is a Th1/Th17 skewing vaccine adjuvant.		Others
T10210	A-9758		ROR
	A-9758 is a RORγ ligand and a selective RORγt inverse agonist (IC50: 5 nM) and exhibits robust potency against IL-17A release. It is effective in suppressing both Th17 differentiation and Th17 effector function. A-9758 s...		ROR
T62925	FASN-IN-5
	FASN-IN-5 (example 11) is a FASN inhibitor that can be used in studies of TH17 or CSF1-mediated diseases or disorders (e.g. cancer, immune disorders, obesity).
T26223	SR1555 HCl	SR-1555,SR1555,SR 1555
	SR1555 is a selective RORγ inverse agonist that inhibits the development and function of TH17 cells, a subset of T cells that have been involved in the pathology of several autoimmune diseases such as rheumatoid arthriti...
T72254	RORγt inverse agonist 26
	RORγt inverse agonist 26, a potent reverse agonist of RORγt, effectively modulates Th17 cell differentiation and suppresses IL-17 production. This compound shows promising potential for researching inflammation and autoi...
T70065	JNJ-61803534
	JNJ-61803534 is a potent, orally active RORγt inverse agonist, demonstrating anti-inflammatory activity through inhibition of IL-17A production in human CD4+ T cells under Th17 differentiation conditions, with an IC50 of...