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3-Oxo-5β-cholanoic acid

Catalog No. T13502 CAS 1553-56-6

Synonyms: Dehydrolithocholic acid

3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM).

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3-Oxo-5β-cholanoic acid Chemical Structure

3-Oxo-5β-cholanoic acid, CAS 1553-56-6

Pack Size	Availability	Price/USD
10 mg	In stock	$ 41.00
25 mg	In stock	$ 63.00
50 mg	In stock	$ 91.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 99.44%

Purity: 98.01%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM).
In vitro	Treatment with 3-Oxo-5β-cholanoic acid notably diminishes the RORγt reporter's activity, likely through direct interaction with RORγt, thereby hindering TH17 cell differentiation by suppressing its transcriptional activity.
In vivo	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w); p.o.; for 1 week) significantly reduces the percentage of ileal TH17 cells[1].

Synonyms	Dehydrolithocholic acid
Molecular Weight	374.56
Formula	C24H38O3
CAS No.	1553-56-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/ml (173.54 mM), Sonication is recommended.

References and Literature

1. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec;576(7785):143-148.

Related compound libraries

This product is contained In the following compound libraries：

Metabolism Compound Library Transcription Factor-Targeted Compound Library Natural Product Library for HTS Nuclear Receptor Compound Library Natural Product Library Kinase Inhibitor Library Bioactive Compound Library Bioactive Compounds Library Max

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Cabozantinib hydrochloride RORγt inverse agonist 14 TMP780 Cedirogant Zymostenol Nobiletin Bevurogant ML 209

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Keywords

3-Oxo-5β-cholanoic acid 1553-56-6 Metabolism ROR cell factor RAR-related orphan receptor 3 Oxo 5β cholanoic acid TH17 RORγt 3-Oxo-5b-cholanoic acid differentiation acid bile Inhibitor responses transcription inhibit Dehydrolithocholic acid 3-Oxo-5beta-cholanoic acid 3Oxo5βcholanoic acid immune 3-oxoLCA inhibitor

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