Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 34.00 | |
2 mg | In stock | $ 48.00 | |
5 mg | In stock | $ 81.00 | |
10 mg | In stock | $ 129.00 | |
25 mg | In stock | $ 229.00 | |
50 mg | In stock | $ 382.00 | |
100 mg | In stock | $ 562.00 | |
200 mg | In stock | $ 785.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 142.00 |
Description | GSK-J4 Hydrochloride (GSK J4 HCl) is a cell permeable, potent and selective histone demethylase(JMJD3 )inhibitor. is an ethyl ester derivative of the GSK-J1 with an IC50 value greater than 50 μM in vitro. |
Targets&IC50 | JMJD3:50 μM, JMJD3 (cell-free assay):60 nM |
In vitro | When administered to human primary macrophages, GSK-J4 can reduce LPS-induced proinflammatory cytokine production, most notably including that of TNFα (IC50 = 9 μM). |
In vivo | Acting as a prodrug, GSK-J4 is rapidly hydrolyzed in cells to the otherwise cell impermeable GSK-J1, which exhibits an IC50 value of 60 nM for the purified enzyme. The histone H3 lysine 27 (H3K27) demethylase JMJD3 plays important roles in the transcriptional regulation of cell differentiation, development, the inflammatory response, and cancer. |
Synonyms | GSK J4 HCl, GSK J4 HCl (1373423-53-0 free base) |
Molecular Weight | 453.97 |
Formula | C24H28ClN5O2 |
CAS No. | 1797983-09-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 20 mg/mL
DMSO: 50 mg/mL (110.14 mM)
You can also refer to dose conversion for different animals. More
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GSK-J4 Hydrochloride 1797983-09-5 Chromatin/Epigenetic Histone Demethylase GSK J4 HCl diabetic Th17 mice cells inflammation Th1 H3K27me3/me2 dendritic GSKJ4 Hydrochloride TGF-β 1373423-53-0 inhibit 1373423-53-0 free base Inhibitor GSK J4 Hydrochloride GSK J4 HCl (1373423-53-0 free base) demethylase GSK-J4 GSK-J-4 Hydrochloride inhibitor