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Ciglitazone

Catalog No. T19710 CAS 74772-77-3

Synonyms: Ciglitazona, U 63287, ADD3878, ADD-3878, U-63287, ADD 3878

Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.

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Ciglitazone, CAS 74772-77-3

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5 mg	In stock	$ 91.00

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Purity: 98.23%

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Storage & Solubility Information

Description	Ciglitazone (ADD 3878) is a potent and selective PPARγ agonist (EC50: 3 μM) and oral hypoglycemic agent. Ciglitazone inhibits proliferation and differentiation of th17 cells, decreases insulin levels, vascular endothelial growth factor production and blood pressure, and induces cell cycle arrest in gastric cancer cells. Selegiline induces apoptosis in opossum kidney epithelial cells and activates nuclear translocation of p38 MAPK and apoptosis-inducing factor (AIF). Ciglitazone exhibits hypoglycaemic activity in animal models of obesity and hyperglycaemia.
Targets&IC50	PPARγ:3 μM(EC50)
In vitro	Ciglitazone (0-20 μM ; 24 hours) ciglitazone causes the generation of ROS and an increase in intracellular Ca2+ and induces apoptosis through a PPAR-independent mechanism.[4]
In vivo	Ciglitazone (100 mg/kg/day ; 2 days ; C57BL/6J-ob/ob mice) elicits a drastic fall in blood glucose.[3] Ciglitazone (100 mg/kg/day ; 41-44 days ; ob/ob mice) degranulation of islet beta-cells and increased pancreatic insulin content are observed.[3]

Synonyms	Ciglitazona, U 63287, ADD3878, ADD-3878, U-63287, ADD 3878
Molecular Weight	333.45
Formula	C18H23NO3S
CAS No.	74772-77-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 90.0 mg/mL (269.9 mM ), Sonication is recommended.

References and Literature

1. Willson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996 ; 39(3):665-668. 2. Kim DH, et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells. Biomol Ther (Seoul). 2015 ; 23(1):71-76. 3. Chang AY, et al. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes. 1983 ; 32(9):830-838. d 4. Kwon CH, et al. Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells. Toxicology. 2009 ; 257(1-2):1-9.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library Anti-Cancer Active Compound Library Cytoskeletal Signaling Pathway Compound Library DNA Damage & Repair Compound Library Bioactive Compounds Library Max Nuclear Receptor Compound Library Immunology/Inflammation Compound Library Bioactive Compound Library Anti-Obesity Compound Library Anti-Cancer Compound Library

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Keywords

Ciglitazone 74772-77-3 Apoptosis DNA Damage/DNA Repair MAPK Metabolism p38 MAPK PPAR Ciglitazona U 63287 ADD3878 ADD-3878 U63287 U-63287 ADD 3878 inhibitor inhibit

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