ror — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T24727	ROR Modulator I	ROR-Modulator-I,RORModulatorI
	ROR Modulator I is the first potent inverse agonist of the retinoid-related orphan receptor. It also has dual selectivity for RORβ and RORγt.
T12750	ROR agonist-1		Others
	ROR agonist-1 is a potent and orally bioavailable the retinoic acid receptor-related orphan receptor C2 (RORC2) inverse agonist(inhibition of IL-17A production from human primary TH 17 cells with a pIC50 of 7.5).		Others
T4050	GSK2981278	ROR gama modulator 1	ROR
	GSK2981278 (ROR gama modulator 1) is a highly potent and selective inverse agonist of retinoic acid receptor-related orphan receptor gamma (ROR gamma).		ROR
T39250	Bevurogant		ROR
	Bevurogant is an antagonist of RORγt receptor and can be used in studies about the treatment of chronic inflammatory diseases.		ROR
T3S1251	Neoruscogenin		ROR
	1. Neoruscogenin represents a universal pharmacological tool for RORα research due to its specific selectivity profile versus other nuclear receptors.		ROR
TQ0007	Cintirorgon	LYC-55716	ROR
	Cintirorgon (LYC-55716) is a selective, oral agonist of RORγ. Cintirorgon modulates gene expression of RORγ expressing T lymphocyte immune cells.		ROR
T5163	SR1001		ROR
	SR 1001 is an inverse agonist for RORα/RORγ (Kis: 172/111 nM).		ROR
T4670	SR0987		ROR
	SR0987 is a RORγt agonist,		ROR
T4594	SR1078	SR 1078	ROR
	SR1078 is an agonist of retinoic acid receptor-related orphan receptor (ROR)α/γ.		ROR
T7388	GSK805		ROR
	GSK805 is a potent, orally bioavailable retinoid-related orphan receptor gamma t (RORγt) inverse agonist that interacts with the receptor's putative ligand binding domain without exerting significant effects on DNA bindi...		ROR
T2834	Nobiletin	Hexamethoxyflavone	Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
	Nobiletin (Hexamethoxyflavone) is a natural polymethoxylated flavone isolated from citrus peels with anti-inflammatory and anti-tumor activities. Nobiletin is practically insoluble (in water) and an extremely weak acidic...		Apoptosis , MMP , Reactive Oxygen Species , ROR , Autophagy
T9635	Cedirogant	ABBV-157	ROR
	Cedirogant (ABBV-157) is an orally active retinoid-related orphan receptor-γt(RORγt) inverse agonist that is used for psoriasis study.		ROR
T16832	S18-000003		ROR
	S18-000003 is an effective orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t inhibitor (IC50: 29 nM). S18-000003 inhibits IL-17 production.		ROR
T12753	RORγt Inverse agonist 6		ROR
	RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.		ROR
T9623	RORγt inverse agonist 13		ROR
	RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist (IC50=63.8 nM), with improved drug-like properties[1].		ROR
T14369	AZD-0284		ROR
	AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].		ROR
T5160	SR3335	ML 176	ROR
	SR3335 (ML 176) is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki: 220 nM).		ROR
T1079	Metronidazole	Flagyl,Metronidazol,Anagiardil	Apoptosis , NADPH , Hydrogenase , Antibacterial , Antibiotic , Parasite , Antifection
	Metronidazole (Metronidazol) is a synthetic nitroimidazole derivative with antiprotozoal and antibacterial activities.
T13502	3-Oxo-5β-cholanoic acid	Dehydrolithocholic acid	ROR
	3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (Dehydrolithocholic acid) is a bile acid metabolite and inhibits the differentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd: 1.13 μM)...		ROR
T6690	T0901317		Apoptosis , FXR , Liver X Receptor , ROR
	T0901317 is a potent and selective agonist for both LXR and FXR, with EC50 of ~50 nM and 5 μM, respectively; it inhibits nuclear factor/κB (NF/κB).		Apoptosis , FXR , Liver X Receptor , ROR