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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T62872 | PDGFR-IN-1 | ||
PDGFR-IN-1 (compound 7m) is an orally active PDGFR (platelet-derived growth factor receptor) inhibitor that acts on PDGFRα (IC50: 2.4 nM) and PDGFRβ (IC50: 0.9 nM). PDGFR-IN-1 exhibits strong anti-tumour effects and low ... | |||
T4332 | C-Kit-IN-1 | PDGFR inhibitor 1,DCC-2618 | c-Met/HGFR , c-Kit |
c-Kit-IN-1 (DCC-2618) is an effective inhibitor of c-Met and c-Kit (IC50s<200 nM). | |||
T5466 | Tyrosine kinase-IN-1 | VEGFR , FGFR , FLT , PDGFR | |
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively) | |||
T2500 | Cediranib | AZD2171,NSC-732208 | VEGFR , FLT , PDGFR , c-Kit , Autophagy |
Cediranib (AZD2171) (AZD2171) is a highly potent (IC50 < 1 nmol/L) ATP-competitive inhibitor of recombinant KDR tyrosine kinase in vitro, also inhibits Flt1/4 (IC50: 5 nM/≤3 nM), similar activity against PDGFRβ and c-Kit... | |||
T4349 | Sitravatinib | MG516,MGCD516 | Discoidin Domain Receptor (DDR) , VEGFR , FLT , Trk receptor , TAM Receptor , c-Kit , Ephrin Receptor |
Sitravatinib (MGCD516) (MGCD516) is an inhibitor targeting multiple RTKs involved in driving sarcoma cell growth, including c-Met, c-Kit, PDGFRα/β, PDGFR, and Axl. | |||
T3211 | Midostaurin | N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251 | Others , PKC |
PKC412(Midostaurin (PKC412); CGP41231; CGP41251) is a broad spectrum protein kinase inhibitor. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c-kit, platel... | |||
T10645 | C-Fms-IN-6 | c-Fms | |
c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM). | |||
T79530 | SA-PA | PROTACs | |
SA-PA, a self-assembled intracellular PROTAC leveraging azide-alkyne click chemistry, selectively degrades VEGFR-2, PDGFR-β, and EphB4 proteins within U87 cells. In the presence of endogenous copper in tumor tissues, SA-... | |||
T28874 | SU11652 | SU-11652,SU 11652 | |
SU11652 is a potent cell-permeable pyrrole-indolinone compound. SU11652 acts as an ATP-competitive tyrosine kinase receptor and angiogenic inhibitor with greater selectivity for PDGFR-β (PDGFRβ, IC50 = 3 nM), Flk-1 (VEGF... | |||
T68286 | CE-245677 mesylate | ||
CE-245677 is a selective, orally active Tie2 kinase inhibitor identified by Pfizer previously in development for the treatment of certain cancers. CE-245,677 is a potent reversible inhibitor of Tie2 and TrkA/B kinases w... | |||
T67442 | CGP-53716 | ||
The growth factors, platelet-derived growth factor (PDGF) and basic fibroblast growth factor (bFGF) play major roles in enhanced smooth muscle cells growth in rodent blood vessels after vascular injury. Tyrosine kinase i... | |||
T77646 | Multi-kinase-IN-5 | ||
Multi-kinase-IN-5 (compound 15c) is a multi-kinase inhibitory agent that shows significant inhibition against a range of protein kinases including RET, KIT, cMet, VEGFR1, VEGFR2, FGFR1, PDGFR, and BRAF, with correspondin... | |||
T73973 | Imatinib Impurity E | ||
Imatinib Impurity E is a specific impurity found in Imatinib, an orally available inhibitor of multiple tyrosine kinases, including BCR/ABL, v-Abl, PDGFR, and c-kit. Imatinib (STI571) operates by semi-competitively inhib... | |||
T29542 | AC708 | AC 708,AC-708 | |
AC708 is a small molecule CSF1R inhibitor that effectively inhibits CSF1R phosphorylation mediated by CSF-1 (IC50 = 26 nM) and IL-34 (IC50 = 33 nM). It also inhibited the activity of growth factor-dependent cells culture... |