nek2 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T28141	Nek2-IN-5	NCL00017509	MAPK
	Nek2-IN-5 (NCL00017509) is a potent and selective inhibitor of NIMA-related kinase 2 (Nek2).		MAPK
T73287	Nek2-IN-6
	Nek2-IN-6 inhibitor .
T11960	MBM-55		GSK-3 , MAPK , DYRK , Akt , Chk , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase
	MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
T8216	T-1101 tosylate	TAI-95 tosylate	Apoptosis , Microtubule Associated
	T-1101 tosylate (TAI-95 tosylate) is an inhibitor of Hec1/Nek2, with antitumor activity.		Apoptosis , Microtubule Associated
T6180	INH6		Apoptosis , Microtubule Associated
	INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.		Apoptosis , Microtubule Associated
T11961	MBM-55S		GSK-3 , MAPK , Akt , Bcr-Abl , CDK , S6 Kinase , Aurora Kinase
	MBM-55S is an effective inhibitor of Nek2 with an IC50 of 1 nM. MBM-55S indecus cell cycle arrest and apoptosis thereby inhibiting the proliferation of cancer cells. MBM-55S shows antitumor activities.
T6691	TAI-1		Apoptosis , Microtubule Associated
	TAI-1 is a potent and specific Hec1 inhibitor, which disrupts Hec1-Nek2 protein interaction.		Apoptosis , Microtubule Associated
T2502	INH1	IBT13131	Apoptosis , Microtubule Associated
	INH1 (IBT13131) is a cell-permeable Hec1 inhibitor that specifically disrupts the Hec1/Nek2 interaction.		Apoptosis , Microtubule Associated
T11657	INH154		Others
	INH154 is a highly potent inhibitor for Nek2 and Hec1 binding (INH), with IC50s of 120 nM and 200 nM for INH in MB468 and Hela cells.		Others
T9880	ZINC05007751		MAPK
	ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.		MAPK
T38710	JH295
	JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alky...
T11959	MBM-17S		Aurora Kinase
	MBM-17S, a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM, effectively inhibits cancer cell proliferation by inducing cell cycle arrest and apoptosis. It demonstrates antitumor activities without evid...		Aurora Kinase
T11958	MBM-17		Aurora Kinase
	MBM-17 is a potent inhibitor of NIMA-related kinase 2 (Nek2,IC50 of 3 nM). It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.		Aurora Kinase
T28498	Rac-CCT-250863
	Rac-CCT-250863, a potent Nek2 inhibitor, exhibits selectivity for Nek2 over PLK1, MPS1, Cdk2 and Aurora A.
T27052	CMP3a	CMP-3a,CMP 3a
	CMP3a is a NEK2 kinase inhibitor. CMP3a efficiently attenuated GBM growth in a mouse model and exhibited a synergistic effect with radiotherapy. Targeting NEK2 attenuates glioblastoma growth and radioresistance by destab...
T24130	HCI-2184	HCI2184,HCI 2184
	HCI-2184 is an inhibitor of AXL kinase and Nek2 that acts by successfully mitigating drug resistance in bortezomib-resistant multiple myeloma.
T81696	NBI-961
	NBI-961, a potent NEK2 inhibitor, suppresses proteasomal degradation and effectively induces G2/mitosis arrest and apoptosis within diffuse large B cell lymphoma (DLBCL) cells [1].
T61061	JH295 hydrate
	JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor that inhibits cellular Nek2 by Cys22 alkylation (IC50 = 770 nM). JH295 hydrate is not active against the mitotic kinases, Cdk1,...
T28498L	Rac-CCT-250863 HCl	rac-CCT-250863 HCl(1364269-06-6 Free base)	Apoptosis
	rac-CCT-250863 HCl is a selective and reversible inhibitor of NEK 2. rac-CCT-250863 HCl induces cell cycle arrest and has good anti-proliferative activity against cancer cells. rac-CCT-250863 HCl can be used in combinati...		Apoptosis