Powder: -20°C for 3 years | In solvent: -80°C for 1 year
INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 42.00 | |
25 mg | In stock | $ 91.00 | |
50 mg | In stock | $ 148.00 | |
100 mg | In stock | $ 279.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 46.00 |
Description | INH6, an effective Hec1 inhibitor, selectively disrupts the Hec1/Nek2 interaction and induces chromosome mis-alignment. |
Targets&IC50 | Hec1:2.4 μM., NEK2:2.4 μM |
In vitro | INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis. [1] |
Cell Research | Standard XTT assays with a four-day drug treatment procedure are performed to measure the dose-dependent cytotoxicity of INH analogs in cultured cells. Triplicate sets are measured and compiled for final data presentation. The assay is performed by using a commercial kit following the instructions. In principle, cells are plated on 96-well dishes one day before the drug treatment, followed by drug treatment on day 2 and XTT assay on day 5 after drug addition. The absorption at 595 nm is measured with a plate reader and converted to cell survival percentages in comparison to mock treated groups.(Only for Reference) |
Molecular Weight | 322.42 |
Formula | C19H18N2OS |
CAS No. | 1001753-24-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ethanol: 9 mg/mL (27.9 mM)
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 60 mg/mL (186.1 mM)
You can also refer to dose conversion for different animals. More
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INH6 1001753-24-7 Apoptosis Cytoskeletal Signaling Microtubule Associated Inhibitor INH 6 inhibit INH-6 inhibitor