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ZINC05007751
🥰Excellent
Catalog No. T9880Cas No. 591239-68-8
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.
ZINC05007751
🥰Excellent
Purity: 99.7%
Catalog No. T9880Cas No. 591239-68-8
ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $51 | In Stock | |
| 2 mg | $74 | In Stock | |
| 5 mg | $122 | In Stock | |
| 10 mg | $197 | In Stock | |
| 25 mg | $372 | In Stock | |
| 50 mg | $597 | In Stock | |
| 100 mg | $852 | In Stock |
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Purity:99.7%
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Product Introduction
Bioactivity
Chemical Properties
| Description | ZINC05007751 is an effective inhibitor of NIMA-related kinase NEK6 (IC50 = 3.4 μM). ZINC05007751 is very selective against NEK1 and NEK6 with no significant activity observed against NEK2, NEK7, and NEK9. |
| Targets&IC50 | NEK6:3.4 μM |
| In vitro | In ovarian cancer cells PEO1, ZINC05007751 induced perturbation of the cell cycle. ZINC05007751 showed synergism with Cisplatin, resulting in a significant reduction of Cisplatin IC50 from 7.9 to 0.1 µM, with a combination of ZINC05007751 (44 µM) + Cisplatin (10 µM) exhibiting the greatest synergistic effect. ZINC05007751 (6 μM-190 μM; 24 hours) inhibited the growth of MDA-MB-231, PEO1, NCI-H1299, and HCT-15 with IC50 below 100 µM[1]. |
| Molecular Weight | 304.3 |
| Formula | C18H12N2O3 |
| Cas No. | 591239-68-8 |
| Smiles | CC1=C(C#N)C(=O)NC(=O)\C1=C/c1ccc(o1)-c1ccccc1 |
| Relative Density. | no data available |
| Color | Black |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 8 mg/mL (26.29 mM), Sonication and heating to 60℃ are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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