nfκb — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T27612	INI-43	INI 43,INI43	Others
	INI-43, an inhibitor of Nuclear Import-43, shows a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnβ1 and interferes with the nuclear localization of Kpnβ1 and known Kpn...		Others
T6761	Ossirene	AS101	IL Receptor , Caspase , Interleukin
	Ossirene (AS101), a potent in vitro and in vivo immunomodulator, is a novel inhibitor of IL-1beta converting enzyme.		IL Receptor , Caspase , Interleukin
T9656	AP-1/NF-κB activation inhibitor 1		NF-κB , DNA/RNA Synthesis
	AP-1/NF-κB activation inhibitor 1 is a potent inhibitor of AP-1 and NF-κB mediated transcriptional activation ( IC 50 =1 μM), does not blocking basal transcription driven by the β-actin promoter. AP-1/NF-κB activation in...		NF-κB , DNA/RNA Synthesis
T8160	EGCG Octaacetate		Others , Antibacterial
	EGCG Octaacetate, a prodrug of EGCG, is utilized to enhance the stability and bioavailability of EGCG in vivo. It has high efficacy, bioavailability, anti-oxidation, and anti-angiogenesis capacities.		Others , Antibacterial
T37559	NF-κB Control
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence (NLS) of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells. It bloc...
T38153	NF-κB Inhibitor (trifluoroacetate salt)
	NF-κB inhibitor is a synthetic peptide corresponding to the nuclear localization sequence of NF-κB p105 subunit (also known as p50) appended to a hydrophobic sequence to facilitate import into living cells.1It blocks the...
T35544	ML115		STAT
	ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.		STAT
T0131	Cepharanthine	NSC-623442	Apoptosis , TNF , HIV Protease , Autophagy
	Cepharanthine (NSC-623442), a biscoclaurine alkaloid, suppresses tumor necrosis factor (TNF)-α-mediated NFκB stimulation, plasma membrane lipid peroxidation and platelet aggregation and inhibits cytokine production.		Apoptosis , TNF , HIV Protease , Autophagy
T5668	Triacetylresveratrol	Acetyl-trans-resveratrol	BCL , NF-κB , STAT
	Triacetylresveratrol (Acetyl-trans-resveratrol) has anti-cancer activity,it inhibits the phosphorylation of STAT3 and NFκB, down-regulates Mcl-1, and up-regulates Bim and Puma in pancreatic cancer cells.		BCL , NF-κB , STAT
T38164	MnTBAP chloride	Mn(III)TBAP
	MnTBAP chloride (Mn(III)TBAP) is a cell-permeable superoxide dismutase (SOD) mimetic and peroxynitrite scavenger that reduces the doubling time of SOD-E. coli by a factor of 2. MnTBAP chloride exhibits anti-inflammatory ...
T4868	Gamma-Linolenic acid	gamolenic acid,γ-Linolenic acid	Endogenous Metabolite
	gamma-Linolenic acid (gamolenic acid), is an unsaturated fatty acid synthesized from linoleic acid (LA) by the enzyme delta-6-desaturase. Research on hepatocellular cell lines has shown γ-Linolenic Acid to have induced r...		Endogenous Metabolite
T5S1607	Morusin	Mulberrochromene	NF-κB , Antibacterial , STAT
	1. Morusin (Mulberrochromene) possesses antitumor effects of cell lines including HT-29, A549, MCF-7, and MDA-MB-231, through suppressing STAT3 and NFκB attenuation mediated apoptosis induction. 2. Morusin possesses anti...		NF-κB , Antibacterial , STAT
T5S0734	Desmethoxyyangonin	Desmethoxy yangonin,Demethoxyyangonin,5,6-Dehydrokavain	Others , Monoamine Oxidase
	1. Desmethoxyyangonin (5,6-Dehydrokavain) protects LPS or LPS/D-GalN-induced damages in cell or liver tissues mainly through de-regulating IKK/NFκB and Jak2/STAT3 signaling pathways. 2. The induction of CYP3A23 by dihydr...		Others , Monoamine Oxidase
T15451	GW-870086		Glucocorticoid Receptor
	GW-870086 is an effective anti-inflammatory agent. GW-870086 also plays a role in a glucocorticoid receptor agonist (pIC50: 10.1 in A549 cells expressing NF-κB).		Glucocorticoid Receptor
T3949	Myristic acid	Crodacid,Tetradecanoic acid,n-Tetradecanoic acid	Others , Endogenous Metabolite
	Myristic acid (Crodacid) , a 14 carbon saturated fatty acid, is a rare molecule in cells and is a substrate of some fatty acid desaturases. This compound has the ability to acylate proteins by covalently binding to the N...		Others , Endogenous Metabolite
T82665	CTP-NBD		NF-κB
	CTP-NBD is a cell-permeable, specific inhibitor of the NFκB peptide, which has been utilized in studies of colitis [1] [2].		NF-κB
T71296	4-Aaqb
	4-Aaqb, also known as OB-318, is a natural inhibitor of the autophagy pathway, enhancing immune function, suppressing MAPK and NFκB, showing anti-inflammatory, hypoglycemic, vasorelaxative, and antiproliferative activiti...
T69243	AK963
	AK963, also known as 40708899, is a potent PAK1 (p21-activated kinase 1) inhibitor, which suppresses the proliferation of human gastric cancer cells significantly by downregulation of PAK1-NFκB-CyclinB1 pathway.
T62239	HSR1304
	HSR1304 (Compound 5d) is a potent inhibitor of NFκB, a multifunctional transcription factor involved in a wide range of human diseases (e.g. cancer, chronic inflammation). HSR1304 has potential for research in cancer dis...
T127402	Coenzyme Q0	CoQ0
	Coenzyme Q0 (CoQ0), a potent, orally active ubiquinone compound derived from Antrodia cinnamomea, induces apoptosis and autophagy. It suppresses HER-2/AKT/mTOR signaling, enhancing apoptosis and autophagy mechanisms. Add...