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Search Results for " mt1 "

20

Compounds

Cat No. Product Name Synonyms Targets
T39461 MT1
MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1).
T1463 Ramelteon TAK-375 Melatonin Receptor , MT Receptor
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist.
T3495 Tasimelteon VEC-162,BMS-214778 Melatonin Receptor , MT Receptor
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
T1445 Agomelatine Thymanax,S-20098,Valdoxan Melatonin Receptor , 5-HT Receptor
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression.
T60129 MT189 Antiproliferative agent-14 Microtubule Associated
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit...
T11064 DMT1 blocker 2 Others
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.
T8841 IMT1 Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) Others , DNA/RNA Synthesis , Mitochondrial Metabolism
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity.
T8842 IMT1B 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 Others , DNA/RNA Synthesis
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it...
T11063 DMT1 blocker 1 Others
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo.
T71739 PTPMT1-IN-1
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor.
T38421 PRMT1-IN-1 PRMT1-IN-1
PRMT1-IN-1 is a PRMT1 inhibitor.
T16834 S26131 N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide MT Receptor
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively.
T9193 ACH-000143 Melatonin Receptor , MT Receptor
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2.
T15795 Luzindole N-0774 Melatonin Receptor , MT Receptor
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1...
T1891 NSC 405020 MMP
NSC 405020 is a noncatalytic inhibitor of MT1-MMP.
T10198 8-M-PDOT 8-Methoxy-2-propionamidotetralin,AH-002 MT Receptor
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to study MT2-induced neuropathic pain.
T10073 2-Iodomelatonin Melatonin Receptor
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin bind...
T28145 ND-322 HCl ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl MMP
ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion.
T34081 Piromelatine NEU-P-11,NEU-P 11,NEU-P11 P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ...
T4093 Fabomotizole hydrochloride Afobazole hydrochloride,CM346 hydrochloride MAO
Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro...

Compounds

MT1
T39461
Synonym:
Target:
Ramelteon
T1463
Synonym: TAK-375
Target: Melatonin Receptor, MT Receptor
Tasimelteon
T3495
Synonym: VEC-162,BMS-214778
Target: Melatonin Receptor, MT Receptor
Agomelatine
T1445
Synonym: Thymanax,S-20098,Valdoxan
Target: Melatonin Receptor, 5-HT Receptor
MT189
T60129
Synonym: Antiproliferative agent-14
Target: Microtubule Associated
DMT1 blocker 2
T11064
Synonym:
Target: Others
IMT1
T8841
Synonym: Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1)
Target: Others, DNA/RNA Synthesis, Mitochondrial Metabolism
IMT1B
T8842
Synonym: 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974
Target: Others, DNA/RNA Synthesis
DMT1 blocker 1
T11063
Synonym:
Target: Others
PTPMT1-IN-1
T71739
Synonym:
Target:
PRMT1-IN-1
T38421
Synonym: PRMT1-IN-1
Target:
S26131
T16834
Synonym: N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide
Target: MT Receptor
ACH-000143
T9193
Synonym:
Target: Melatonin Receptor, MT Receptor
Luzindole
T15795
Synonym: N-0774
Target: Melatonin Receptor, MT Receptor
NSC 405020
T1891
Synonym:
Target: MMP
8-M-PDOT
T10198
Synonym: 8-Methoxy-2-propionamidotetralin,AH-002
Target: MT Receptor
2-Iodomelatonin
T10073
Synonym:
Target: Melatonin Receptor
ND-322 HCl
T28145
Synonym: ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl
Target: MMP
Piromelatine
T34081
Synonym: NEU-P-11,NEU-P 11,NEU-P11
Target: P2X Receptor, 5-HT Receptor, MT Receptor, Sodium Channel, TRP/TRPV Channel
Fabomotizole hydrochloride
T4093
Synonym: Afobazole hydrochloride,CM346 hydrochloride
Target: MAO
1 2
TargetMol