20
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T39461 | MT1 | ||
MT1, a bivalent chemical probe targeting BET bromodomains, demonstrates an IC50 value of 0.789 nM for BRD4(1). | |||
T1463 | Ramelteon | TAK-375 | Melatonin Receptor , MT Receptor |
Ramelteon (TAK-375) is a Melatonin Receptor Agonist. The mechanism of action of ramelteon is as a Melatonin Receptor Agonist. | |||
T3495 | Tasimelteon | VEC-162,BMS-214778 | Melatonin Receptor , MT Receptor |
Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals. | |||
T1445 | Agomelatine | Thymanax,S-20098,Valdoxan | Melatonin Receptor , 5-HT Receptor |
Agomelatine (Valdoxan) is structurally closely related to melatonin. Agomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin-2C (5-HT2C) receptors, tested in an animal model of depression. | |||
T60129 | MT189 | Antiproliferative agent-14 | Microtubule Associated |
MT189 (Antiproliferative agent-14) is a potent tubulin polymerization inhibitor, with an IC50 of 3.41 μM. Antiproliferative agent-14 has excellent antiproliferative activity. Antiproliferative agent-14 possess the abilit... | |||
T11064 | DMT1 blocker 2 | Others | |
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo. | |||
T8841 | IMT1 | Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-,LDC195943(IMT1) | Others , DNA/RNA Synthesis , Mitochondrial Metabolism |
IMT1 (Propanamide, N,N-dimethyl-2-[[4-(2-methylphenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-) has anticancer activity. | |||
T8842 | IMT1B | 3-Piperidinecarboxylic acid, 1-[(2R)-2-[[4-(2-chloro-4-fluorophenyl)-2-oxo-2H-1-benzopyran-7-yl]oxy]-1-oxopropyl]-, (3S)-,LDC203974 | Others , DNA/RNA Synthesis |
IMT1B (LDC203974) is an orally administered, specific noncompetitive allosteric inhibitor of the mitochondrial RNA polymerase (POLRMT), effectively suppressing mitochondrial DNA (mtDNA) expression. This action confers it... | |||
T11063 | DMT1 blocker 1 | Others | |
DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo. | |||
T71739 | PTPMT1-IN-1 | ||
PTPMT1-IN-1 is a PTEN-like mitochondrial phosphatase PTPMT1 inhibitor. | |||
T38421 | PRMT1-IN-1 | PRMT1-IN-1 | |
PRMT1-IN-1 is a PRMT1 inhibitor. | |||
T16834 | S26131 | N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide | MT Receptor |
S26131 (N-[2-[7-[3-[8-(2-acetamidoethyl)naphthalen-2-yl]oxypropoxy]naphthalen-1-yl]ethyl]acetamide) behaves as an antagonist on MT1 and MT2 receptors with Ki of 0.5 and 112 nM respectively. | |||
T9193 | ACH-000143 | Melatonin Receptor , MT Receptor | |
ACH-000143 have been identified as a novel agonist of the melatonin receptors MT1 and MT2. | |||
T15795 | Luzindole | N-0774 | Melatonin Receptor , MT Receptor |
Luzindole (N-0774) is a selective melatonin receptor antagonist. Luzindole inhibits experimental autoimmune encephalomyelitis and exerts antidepressant-like activity. Luzindole preferentially targets MT2 (Mel1b) over MT1... | |||
T1891 | NSC 405020 | MMP | |
NSC 405020 is a noncatalytic inhibitor of MT1-MMP. | |||
T10198 | 8-M-PDOT | 8-Methoxy-2-propionamidotetralin,AH-002 | MT Receptor |
8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to study MT2-induced neuropathic pain. | |||
T10073 | 2-Iodomelatonin | Melatonin Receptor | |
2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1 over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin bind... | |||
T28145 | ND-322 HCl | ND 322 Hydrochloride,ND322 Hydrochloride,ND-322 Hydrochloride,ND322 HCl | MMP |
ND-322 HCl (ND 322 Hydrochloride) is a selective inhibitor of MT1-MMP and MMP2 and reduces in vitro melanoma cell growth, migration and invasion. | |||
T34081 | Piromelatine | NEU-P-11,NEU-P 11,NEU-P11 | P2X Receptor , 5-HT Receptor , MT Receptor , Sodium Channel , TRP/TRPV Channel |
Piromelatine is an agonist of melatonin MT1/MT2 receptors, 5-HT1A and 5-HT1D, and an antagonist of 5-HT2B.Piromelatine has antinociceptive activity with inhibitory effects on P2X3, TRPV1, and Nav1.7 channels, and can be ... | |||
T4093 | Fabomotizole hydrochloride | Afobazole hydrochloride,CM346 hydrochloride | MAO |
Fabomotizole hydrochloride (CM346 hydrochloride), an anxiolytic drug, produces anxiolytic and neuroprotective effects. The mechanism of Afobazole remains poorly defined, however, with GABAergic, NGF, and BDNF release pro... |