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Tasimelteon

Name: Tasimelteon
Brand: TargetMol
SKU: T3495
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T3495Cas No. 609799-22-6

Alias VEC-162, BMS-214778

Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.

Tasimelteon

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Purity: 99.93%

Catalog No. T3495Alias VEC-162, BMS-214778Cas No. 609799-22-6

Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.

Pack Size	Price	Availability
10 mg	$38	In Stock
25 mg	$68	In Stock
50 mg	$113	In Stock
100 mg	$189	In Stock
500 mg	$473	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Batch Information

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Purity:99.93%

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COA

Product Introduction

Bioactivity

Description	Tasimelteon (BMS-214778) is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
Targets&IC50	MT2 receptor:9.8(pKi), MT1 receptor:9.45(pKi)
Synonyms	VEC-162, BMS-214778

Chemical Properties

Molecular Weight	245.32
Formula	C₁₅H₁₉NO₂
Cas No.	609799-22-6
Smiles	CCC(=O)NC[C@@H]1C[C@H]1c1cccc2OCCc12
Relative Density.	1.145 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (203.82 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.0763 mL	20.3815 mL	40.7631 mL	203.8154 mL
5 mM	0.8153 mL	4.0763 mL	8.1526 mL	40.7631 mL
10 mM	0.4076 mL	2.0382 mL	4.0763 mL	20.3815 mL
20 mM	0.2038 mL	1.0191 mL	2.0382 mL	10.1908 mL
50 mM	0.0815 mL	0.4076 mL	0.8153 mL	4.0763 mL
100 mM	0.0408 mL	0.2038 mL	0.4076 mL	2.0382 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc