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Tasimelteon

Catalog No. T3495 CAS 609799-22-6

Synonyms: 他司美琼, VEC-162, BMS-214778

Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.

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Tasimelteon, CAS 609799-22-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tasimelteon is a melatonin receptor agonist that is used for the treatment of non-24 hour sleep-wake disorder in blind individuals.
Targets&IC50	MT1 receptor:9.45(pKi), MT2 receptor:9.8(pKi)

Synonyms	他司美琼, VEC-162, BMS-214778
Molecular Weight	245.322
Formula	C15H19NO2
CAS No.	609799-22-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 33 mg/mL

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Leger D, et al. Safety profile of tasimelteon, a melatonin MT1 and MT2 receptor agonist: pooled safety analyses from six clinical studies. Expert Opin Drug Saf. 2015;14(11):1673-85. 2. Keating GM, et al. Tasimelteon: A Review in Non-24-Hour Sleep-Wake Disorder in Totally Blind Individuals. CNS Drugs. 2016 Mar 22.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Histamine & Melatonin Receptor-Targeted Compound Library Drug-induced Liver Injury (DILI) Compound Library Drug Repurposing Compound Library FDA-Approved Drug Library Neuronal Signaling Compound Library Approved Drug Library FDA-Approved & Pharmacopeia Drug Library Target-Focused Phenotypic Screening Library Bioactive Compound Library

Related Products

Related compounds with same targets

ACH-000143 N-ACETYLTRYPTAMINE Tasimelteon Melatonin Luzindole Ramelteon Agomelatine 4-P-PDOT

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tasimelteon 609799-22-6 G蛋白偶联受体神经科学 Melatonin Receptor MT Receptor orally BMS214778 MT2 DMRA MT1 Inhibitor BMS 214778 regulator VEC-162 Non-24 inhibit BMS-214778 VEC 162 VEC162 circadian inhibitor

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