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8-M-PDOT

Catalog No. T10198 CAS 134865-70-6

Synonyms: 8-Methoxy-2-propionamidotetralin, AH-002

8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to study MT2-induced neuropathic pain.

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8-M-PDOT, CAS 134865-70-6

Pack Size	Availability	Price/USD
2 mg	In stock	$ 107.00
10 mg	In stock	$ 477.00
50 mg	6-8 weeks	$ 755.00
100 mg	6-8 weeks	$ 1,190.00
1 mL * 10 mM (in DMSO)	In stock	$ 162.00

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Purity: 99.54%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	8-M-PDOT (AH-002) is a selective and potent melatonin MT2 receptor agonist that also inhibits MT1 receptors.8-M-PDOT has anxiolytic activity and may be used to study MT2-induced neuropathic pain.
Targets&IC50	MT1 receptor:8.95 (pKi), MT2 receptor:8.23 (pKi)
In vivo	Treatment with 8-M-PDOT (10 µg/µL; administered into the dorsal striatum by bilateral cannulas; for 30 minutes; male Wistar rats) demonstrates an anxiolytic-like effect[2].
Animal Research	Animal Model: Male Wistar rats (280-320 g) with Rotenone [2]. Dosage: 10 μg/μL. Administration: Administrated into the dorsal striatum by bilateral cannulas; for 30 minutes

Synonyms	8-Methoxy-2-propionamidotetralin, AH-002
Molecular Weight	233.31
Formula	C14H19NO2
CAS No.	134865-70-6

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (214.31 mM), Sonification is recommended.

References and Literature

1. Noseda AC, et al. REM sleep deprivation promotes a dopaminergic influence in the striatal MT2 anxiolytic-like effects. Sleep Sci. 2016 Jan-Mar;9(1):47-54. 2. Browning C, et al. Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors. Br J Pharmacol. 2000 Mar;129(5):877-86.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

8-M-PDOT 134865-70-6 Neuroscience MT Receptor AH 002 8 M PDOT AH002 8MPDOT 8-Methoxy-2-propionamidotetralin AH-002 inhibitor inhibit

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