19
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T38707 | MPC-0767 | ||
MPC-0767, a potent, selective, and orally active hsp90 inhibitor, is the L-alanine ester prodrug of MPC-3100, exhibiting enhanced chemical stability. | |||
T13298 | Verubulin hydrochloride | MPC-6827 hydrochloride | Microtubule Associated |
Verubulin hydrochloride (MPC-6827 hydrochloride) is an agent of blood brain barrier permeable microtubule-disrupting, with potent and broad-spectrum cytotoxic activities,with potent anticancer activity in human MX-1 brea... | |||
T21600 | MPC-3100 | ||
MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with significant antitumor activity [1]. | |||
T5782 | Bevirimat | YK FH312,MPC-4326,PA-457 | HIV Protease |
Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation. | |||
T17229 | Verubulin | MPC 6827 | Microtubule Associated |
Verubulin is a microtubule-disrupting agent with potent and broad-spectrum in vitro and in vivo cytotoxic activities. | |||
T5376 | Aranidipine | MPC1304 | Calcium Channel |
Aranidipine (MPC1304) (MPC1304) is a calcium channel antagonist with potent and long-lasting antihypertensive effects. | |||
T5843 | Tarenflurbil | MPC7869,(R)-Flurbiprofen,R-flurbiprofen | Retinoid Receptor , Autophagy |
Tarenflurbil ((R)-Flurbiprofen) is the non-cyclooxygenase inhibiting R-enantiomer of the non-steroidal anti-inflammatory drug flurbiprofen, which was assessed as a remedy for Alzheimer's disease. | |||
T1768 | 7ACC2 | Mitochondrial Metabolism , Monocarboxylate transporter | |
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for [14C]-lactate influx; new antitumor treatment targeting lactate transport in Y cells. | |||
T2607 | MSDC 0160 | CAY10415,Mitoglitazone,MSDC0160,MSDC-0160 | Others , IGF-1R , Mitochondrial Metabolism |
MSDC 0160 (CAY10415) is a prototype mTOT-modulating insulin sensitizer being used in trials studying the treatment of Type 2 Diabetes and Alzheimer's Disease. | |||
T9235 | GW604714X | 2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]- | Mitochondrial Metabolism |
GW604714X (2,4-Thiazolidinedione, 5-[[5-[6-(4-acetyl-1-piperazinyl)-3-nitro-2-pyridinyl]-2-fluorophenyl]methylene]-) were found to be potent inhibitors of mitochondrial respiration supported by pyruvate | |||
T71538 | AMPCP | ||
AMPCP is an Ecto-5'-nucleotidase (CD73) inhibitor. | |||
T74285 | EDMPC | ||
EDMPC, a cationic lipid, exhibits an enhanced capability for DNA delivery to pulmonary tissues. It facilitates intralobar DNA transfer in rodents [1]. | |||
T79693 | PIMPC | GSK-3 | |
PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits potential therapeutic effects for Alzheimer's disease [1]. | |||
T39792 | AMPC | ||
AMPC, a powerful and efficient inhibitor of TFF3, demonstrates inhibitory effects on cell proliferation, survival, oncogenicity, and CSC-like behavior in TFF3-positive CMS4 CRC cells. It acts as a promising standalone an... | |||
T60419 | Cyclic HPMPC | ||
Cyclic HPMPC is a potent antiviral agent that enhances arterial oxygen saturation in mice infected with the lethal vaccinia virus (IHD strain) and alleviates congenital guinea pig cytomegalovirus (GPCMV) infection outcom... | |||
T24495 | MPCI | ||
MPCI is a selective melanocortin-4 receptor antagonist. | |||
T4441 | UK-5099 | UK 5099,PF-1005023,UK5099 | Others , Mitochondrial Metabolism |
UK-5099 (PF-1005023) is a specific and potent inhibitor of MPC carrier activity [1]. It potently inhibits pyruvate-dependent oxygen consumption by rat heart mitochondria (IC50: 50 nM) [1]. | |||
T38715 | MSDC-0602K | MSDC-0602K,Azemiglitazone potassium | PPAR |
MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (... | |||
T4639 | Azemiglitazone | MSDC 0602 | Mitochondrial Metabolism , mTOR |
Azemiglitazone (MSDC 0602) is an insulin sensitizer potentially for the treatment of diabetes. |