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Bevirimat

Catalog No. T5782 CAS 174022-42-5

Synonyms: YK FH312, MPC-4326, PA-457

Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.

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Bevirimat, CAS 174022-42-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 47.00
5 mg	In stock	$ 97.00
10 mg	In stock	$ 163.00
25 mg	In stock	$ 363.00
50 mg	In stock	$ 538.00
100 mg	In stock	$ 768.00
1 mL * 10 mM (in DMSO)	In stock	$ 125.00

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Purity: 99.58%

Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Bevirimat (PA-457) is a first-in-class inhibitor of HIV-1 maturation, blocking the cleavage of the Gag capsid (CA) precursor, CA-SPI, to mature CA protein during virion maturation.
In vivo	PA-457 reduced viral load in HIV-infected adults in a dose-dependent fashion, when given in a single oral dose in a clinical study[1].
Source	Natural Products > Rhamnaceae > Ziziphus

Synonyms	YK FH312, MPC-4326, PA-457
Molecular Weight	584.83
Formula	C36H56O6
CAS No.	174022-42-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (85.49 mM)

References and Literature

1. Smith P F , Ogundele A , Forrest A , et al. Phase I and II Study of the Safety, Virologic Effect, and Pharmacokinetics/Pharmacodynamics of Single-Dose 3-O-(3′,3′-Dimethylsuccinyl)Betulinic Acid (Bevirimat) against Human Immunodeficiency Virus Infection[J]. Antimicrobial Agents & Chemotherapy, 2007, 51(10):3574. 2. Purdy MD, Shi D, Chrustowicz J,et al.MicroED structures of HIV-1 Gag CTD-SP1 reveal binding interactions with the maturation inhibitor bevirimat[J].Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):13258-13263. 3. Stoddart C A , Pheroze J , Barbara S , et al. Potent Activity of the HIV-1 Maturation Inhibitor Bevirimat in SCID-hu Thy/Liv Mice[J]. PLoS ONE, 2007, 2(11):e1251-.

Related compound libraries

This product is contained In the following compound libraries：

Drug Repurposing Compound Library Inhibitor Library Natural Product Library for HTS Anti-COVID-19 Compound Library Clinical Compound Library Food as Medicine Compound Library Anti-virus Traditional Chinese Medicine Monomer Library Bioactive Compound Library Traditional Chinese Medicine Monomer Library Human Metabolite Library

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Dose Conversion

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In vivo Formulation Calculator (Clear solution)

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Bevirimat 174022-42-5 Microbiology/Virology Proteases/Proteasome HIV Protease YK FH312 YK FH 312 Human immunodeficiency virus MPC-4326 MPC 4326 PA-457 PA 457 HIV YK FH-312 Inhibitor PA457 inhibit MPC4326 inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.