ltb4 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T10917	LTB4-IN-1	Anti-inflammatory agent 2	LTR
	LTB4-IN-1 (Anti-inflammatory agent 2) with IC50 of 70 nM is an inhibitor of leukotriene synthesis (LTB4).		LTR
T78677	LTB4 antagonist 2		Leukotriene Receptor
	LTB4 antagonist 2, a carboxamide-acid compound, serves as an antagonist to leukotriene B4 (LTB4), possessing potential anti-inflammatory properties. It exhibits high affinity for the LTB4 receptor, with an inhibitory con...		Leukotriene Receptor
T72625	LTB4 antagonist 1		Leukotriene Receptor
	LTB4 Antagonist 1, a carboxamide-acid derivative, potently inhibits Leukotriene B4 (LTB4) activity with an IC50 value of 288 nM and exhibits notable anti-inflammatory properties [1].		Leukotriene Receptor
T78678	LTB4 antagonist 3		Leukotriene Receptor
	Compound 24e, a leukotriene B4 (LTB4) antagonist, exhibits an inhibitory concentration 50 (IC50) of 477 nM and demonstrates anti-inflammatory activity [1].		Leukotriene Receptor
T79389	LTB4-IN-2		FLAP
	LTB4-IN-2 (Compound 6x) is a selective inhibitor of Leukotriene B4 (LTB4), acting by specifically targeting the 5-Lipoxygenase-activating protein (FLAP) with an inhibitory concentration (IC 50) of 1.15 μM, thus serving a...		FLAP
T22946	LY255283	LY 255283	Leukotriene Receptor
	LY255283 is a specific antagonit of leukotriene B4 (LTB4) receptor. It inhibits the production of LTB(4) in human peripheral blood polymorphonuclear leukocytes (PMNL) and in monocytes activated by calcium ionophore A2318...		Leukotriene Receptor
T14045	Leukotriene B4	LTB4,5(S),12(R)-DiHETE	Others
	Leukotriene B4 is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1].		Others
T17191	Bunaprolast	U66858	Lipoxygenase , LTR
	Bunaprolast (U66858) is a novel and potent leukotriene B4 (LTB4) inhibitor.Bunaprolast exhibits oxidative degradation activity and inhibits lipoxygenase and TXB2 release.		Lipoxygenase , LTR
T15002	CP-105696	Pfizer 105696	LTR
	CP-105696 is a potent and selective leukotriene B4 (LTB4) receptor antagonist for the study of allograft rejection.		LTR
T21504	γ-Linolenic Acid methyl ester	Methyl gamma-linolenate	LTR
	γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.		LTR
T11487	Fiboflapon	GSK2190915,AM-803	FLAP
	Fiboflapon (GSK2190915) is an orally available and effective 5-lipoxygenase-activating protein (FLAP) inhibitor that binds FLAP with a titer of 2.9 nM and inhibition of LTB4 in human blood with an IC50 of 76 nM.		FLAP
T28974	Ticolubant		Calcium Channel , LTR
	Ticolubant is orally active leukotriene B4 antagonist with high affinity for the human neutrophil LTB4 receptor (Ki = 0.78 nM), blocks LTB4-induced Ca2+ migration with an IC50 of 6.6 ± 1.5 nM, and shows topical anti-inf...		Calcium Channel , LTR
T22358	Etalocib	LY293111,VML295	Apoptosis , Leukotriene Receptor , LTR
	Etalocib (LY293111) is a novel diaryl ether carboxylic acid derivative, is a selective and potent inhibitor of the lipoxygenase pathway either via antagonism of the leukotriene B4 (LTB4) receptor or directly through 5'-l...		Apoptosis , Leukotriene Receptor , LTR
T10960	Darbufelone	CI-1004	Prostaglandin Receptor , LTR
	Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.		Prostaglandin Receptor , LTR
T10960L	Darbufelone mesylate	CI-1004 mesylate	Prostaglandin Receptor , LTR
	Darbufelone mesylate (CI-1004 mesylate) inhibited PGF2α and LTB4 in cells. Darbufelone mesylate inhibited PGHS-2 with IC50 value of 0.19 μM and PGHS-1 with IC50 value of 20 μM.		Prostaglandin Receptor , LTR
T9878	Croconazole		Lipoxygenase , LTR
	Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic agent. The IC50s for the synthesis of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraeno...		Lipoxygenase , LTR
T68155	Tebufelone		Prostaglandin Receptor , LTR
	Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticul...		Prostaglandin Receptor , LTR
T11699	J-113863		CCR
	J-113863 is also a potent antagonist of the human CCR3 (IC50 of 0.58 nM) , but a weak antagonist of the mouse CCR3 (IC50 of 460 nM). J-113863 is inactive against CCR2, CCR4 and CCR5, as well as the LTB4 or TNF-α receptor...		CCR
T7786	Tryptanthrin		DNA gyrase
	Tryptanthrin is a natural DNA gyrase inhibitor.		DNA gyrase
T3868	Agnuside	chasteberry oil	COX , Prostaglandin Receptor , P-gp
	Agnuside (chasteberry oil) inhibits COX-2 (IC50: 0.026 mg/ml) but exhibits less than 10% inhibition of COX-1 at this concentration. It also inhibits 46.3, 66.8, and 82.1% of P-glycoprotein (P-gp) ATPase activity at conce...		COX , Prostaglandin Receptor , P-gp