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Darbufelone

Darbufelone
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Purity:99.77%
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Darbufelone

Catalog No. T10960Cas No. 139226-28-1
Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.
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Pack SizePriceAvailabilityQuantity
1 mg$37In Stock
5 mg$79In Stock
10 mg$133In Stock
25 mg$294In Stock
50 mg$429In Stock
100 mg$592In Stock
500 mg$1,180In Stock
1 mL x 10 mM (in DMSO)$112In Stock
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Product Introduction

Bioactivity
Description
Darbufelone (CI-1004) is a non-competitive dual inhibitor of PGF2α and LTB4. Dabfilon effectively inhibits PGHS-2 with a Ki of 10 μM and IC50s of 0.19 μM and 20 μM for PGHS-2 and PGHS-1.
In vitro
Darbufelone (5 - 60 μM) increases the cell growth inhibitory effects in A549, H520 and H460 cell lines with IC50s of 20, 21 and 15 μM[2].
In vivo
Darbufelone (80 mg/kg/day) decreases the tumor volumes in a time-dependent manner. Darbufelone (20 or 40 mg/kg/day) dos not show any significant inhibition of tumor weight. At necropsy, Darbufelone (80 mg/kg/day) reduces the tumor weight by 30.2%[2].
AliasCI-1004
Chemical Properties
Molecular Weight332.46
FormulaC18H24N2O2S
Cas No.139226-28-1
Storage & Solubility Information
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 45 mg/mL (135.35 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0079 mL15.0394 mL30.0788 mL150.3940 mL
5 mM0.6016 mL3.0079 mL6.0158 mL30.0788 mL
10 mM0.3008 mL1.5039 mL3.0079 mL15.0394 mL
20 mM0.1504 mL0.7520 mL1.5039 mL7.5197 mL
50 mM0.0602 mL0.3008 mL0.6016 mL3.0079 mL
100 mM0.0301 mL0.1504 mL0.3008 mL1.5039 mL

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Preparation method for in vivo formula: Take 50 μLDMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify.
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