Search Result

Search Results for " lc3 "

Targets

Compounds

Natural Products

Recombinant Proteins

Cat No.	Product Name	Synonyms	Targets
T8081	LC3-mHTT-IN-AN1		Others , Autophagy , ATTECs
	LC3-mHTT-IN-AN1 is a mHTT-LC3 linker compound that interacts with both mutant huntingtin protein (mHTT) and LC3B. LC3-mHTT-IN-AN1 targeted mHTT to autophagosomes reduces the levels of mHTT in an allele-selective manner...		Others , Autophagy , ATTECs
T8903	Retro-2	Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}	Others , Virus Protease , Parasite , Autophagy
	Retro-2 (2-{[(5-methyl-2-thienyl)methylene]amino}) is a plant toxin ricin inhibitor, itprotects HeLa cells against Ricin, Stx1 and Stx2, selectively blocks retrograde toxin trafficking at the early endosome-TGN (trans-Go...		Others , Virus Protease , Parasite , Autophagy
T36250	Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine	Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine
	Functionalized cereblon ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkylC1-PEG3-alkylC3 linker with terminal amine ready for conjugation to a target protein ligand. Part of a ra...
T36279	VH 032 amide-alkylC3-amine	VH 032 amide-alkylC3-amine
	Functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC research and development; incorporates an E3 ligase ligand plus an alkyl C3 linker and terminal amine ready for conjugation to a target protein ligand. Pa...
T36278	VH 032 amide-alkylC3-acid	VH 032 amide-alkylC3-acid
	Functionalized von-Hippel-Lindau protein ligand (VHL) for research and development; incorporates an E3 ligase ligand plus alkylC3 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Par...
T61871	DC-LC3in-D5
	DC-LC3in-D5 is a chemical compound that functions as an autophagy inhibitor by diminishing the process of LC3B lipidation. It forms a binding association with LC3B, disrupting the LC3B-LBP2 interaction with an IC50 of 20...
T116970	TLC3407-3786
	MMV665916 is a quinazolinedione derivative that is an antimalarial agent. MMV665916 shows remarkable antiplasmodial activity against P. falciparum FcB1 strain with EC 50 value of 0.4 μM and presents the high selectivity ...
T23716	AMDE-1	AMDE 1	Autophagy
	AMDE-1 is an autophagy modulator and triggers autophagy in an Atg5-dependent manner. AMDE-1 recruits Atg16 to the pre-autophagosomal site and causes LC3 lipidation.		Autophagy
T19188	ALLO-1		Autophagy
	ALLO-1 is a crucial autophagy receptor responsible for facilitating the formation of autophagosomes around paternal organelles. It directly interacts with the worm LC3 homologue, LGG-1, through its LC3-interacting region...		Autophagy
T27187	DK-1-49
	DK-1-49 is an autophagonizer. It causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles.
T71151	Z36
	Z36 is a novel Bcl-xL inhibitor, upregulating the expression levels of FAM134B, LC3, and Atg9, inducing autophagy along with autophagic cell death, resulting in ER stress and the unfolded protein response (UPR).
T83945	XIE62-1004
	XIE62-1004 is a chemical compound that induces the interaction between p62 and LC3 by binding to the ZZ domain of p62. This interaction promotes p62 self-aggregation and its subsequent interaction with LC3 on autophagoso...
T60453	TrxR-IN-3
	TrxR-IN-3 (Compound 2c) is a effective TrxR inhibitor. TrxR-IN-3 shows strong antiproliferative activities against five human cancer cell lines, especially against breast tumor cells. TrxR-IN-3 increases ROS levels and l...
T76599	Ac-Leu-Val-Lys-Aldehyde
	Ac-Leu-Val-Lys-Aldehyde is a potent inhibitor of cathepsin B, exhibiting inhibitory concentration (IC50) values of 4 nM. It notably diminishes cell death in the striatum induced by quinolinic acid and leads to the accumu...
T61580	Autophagy inducer 3
	Autophagy Inducer 3 is a chemical compound that exhibits autophagy-induced activity, specifically inducing robust autophagic cell death in various cancer cells while sparing normal cells. This compound induces lethal aut...
T83765	Dendrogenin A	DDA
	Dendrogenin A (DDA) is a compound acting as a selective liver X receptor (LXR) modulator, cholesterol epoxide hydrolase inhibitor (Ki = 120 nM), and a metabolic product of cholesterol, originating from 5,6α-epoxy cholest...
T35747	Quinacrine analog 34
	Quinacrine is a compound with multiple actions that is commonly used as an anti-protozoal agent. It has also been shown to be a highly potent autophagy inhibitor, although the dose required to achieve this effect is cons...

Compounds

LC3-mHTT-IN-AN1

T8081

Synonym:

Target: Others, Autophagy, ATTECs

Retro-2

T8903

Synonym: Retro 2,2-{[(5-methyl-2-thienyl)methylene]amino}

Target: Others, Virus Protease, Parasite, Autophagy

Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

T36250

Synonym: Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Target:

VH 032 amide-alkylC3-amine

T36279

Synonym: VH 032 amide-alkylC3-amine

Target:

VH 032 amide-alkylC3-acid

T36278

Synonym: VH 032 amide-alkylC3-acid

Ac-Leu-Val-Lys-Aldehyde

Cat No.	Product Name	Synonyms	Targets
T5070	LC3-mHTT-IN-AN2	5,7-Dihydroxy-4-phenylcoumarin	Antibacterial , Autophagy , ATTECs
	LC3-mHTT-IN-AN2 (5,7-Dihydroxy-4-phenylcoumarin) is found in the plant Passiflora serratodigitata with the antibacterial activity.		Antibacterial , Autophagy , ATTECs
T1152	Albendazole	SKF-62979	HIF/HIF Prolyl-Hydroxylase , Microtubule Associated , Antibiotic , Parasite
	Albendazole (SKF-62979) is used as a drug indicated for the treatment of a variety of worm infestations.
T8166	Pennogenin 3-O-beta-chacotrioside		Autophagy
	Pennogenin 3-O-beta-chacotrioside is an active component isolated from Paris polyphylla with anti-colorectal cancer activity. It modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Be...		Autophagy

Natural Products

LC3-mHTT-IN-AN2

T5070

Synonym: 5,7-Dihydroxy-4-phenylcoumarin

Target: Antibacterial, Autophagy, ATTECs

Albendazole

T1152

Synonym: SKF-62979

Target: HIF/HIF Prolyl-Hydroxylase, Microtubule Associated, Antibiotic, Parasite

Pennogenin 3-O-beta-chacotrioside

T8166

Synonym:

Target: Autophagy

Recombinant Proteins

Species：

Expression System：

Tag：

Cat No.	Product Name	Species	Expression System
TMPJ-01321	MAP1LC3B Protein, Human, Recombinant	Human	E. coli
	Microtubule-associated proteins 1A/1B light chain 3B (MAP1LC3B) is a member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. MAP1LC3B is one of the four genes in t...
TMPY-03340	MAP1LC3A Protein, Human, Recombinant (His)	Human	E. coli
	LC3A, also known as MAP1LC3A, is one of the light chain subunits that function together with both MAP1A and/or MAP1B. MAP1A and MAP1B are microtubule-associated proteins that mediate the physical interactions between mic...
TMPY-03749	LC3B Protein, Human, Recombinant (His)	Human	E. coli
	MAP1LC3B (Microtubule Associated Protein 1 Light Chain 3 beta, also known as LC3B) is a Protein Coding gene. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are in...
TMPH-02324	SLC39A6 Protein, Human, Recombinant (His)	Human	Baculovirus Insect Cells
	May act as a zinc-influx transporter. SLC39A6 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with C-6xHis tag. The predicted molecular weight is 35.0 kDa and the accession number is Q13433.
TMPH-02322	SLC30A10 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	SLC30A10 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 27.9 kDa and the accession number is Q6XR72.
TMPH-01468	SLC31A1 Protein, Human, Recombinant (His & SUMO)	Human	E. coli
	SLC31A1 Protein, Human, Recombinant (His & SUMO) is expressed in in vitro E. coli expression system.
TMPH-02979	SLC30A8 Protein, Mouse, Recombinant (His)	Mouse	E. coli
	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-...
TMPH-01684	MAP1LC3C Protein, Human, Recombinant (His)	Human	E. coli
	Ubiquitin-like modifier that plays a crucial role in antibacterial autophagy (xenophagy) through the selective binding of CALCOCO2. Recruits all ATG8 family members to infecting bacteria such as S.Typhimurium. May also p...
TMPY-06226	SLC39A6/LIV-1 Protein, Cynomolgus, Recombinant (His)	Cynomolgus	HEK293 Cells
	Along with the SLC30 family, SLC39 family members regulate zinc movement in cells. SLC39 metal ion transporters accumulate zinc into the cytosol. SLC39A6, also known as LIV-1, belongs to a new subfamily of Zrt, Irt-like ...
TMPH-02323	SLC30A8 Protein, Human, Recombinant (His)	Human	E. coli
	Facilitates the accumulation of zinc from the cytoplasm into intracellular vesicles, being a zinc-efflux transporter. May be a major component for providing zinc to insulin maturation and/or storage processes in insulin-...
TMPY-00587	GABARAP Protein, Human, Recombinant (His & MBP)	Human	E. coli
	The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in...
TMPH-02282	Ubiquilin-1 Protein, Human, Recombinant (His & Myc)	Human	E. coli
	Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and endoplasmic reticulum-associated protein degradation (ERAD) pa...
TMPY-03461	GABARAPL2 Protein, Human, Recombinant (His)	Human	E. coli
	GATE-16, also known as ATG8, belongs to the MAP1 LC3 family. It is expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. GATE-16 is expressed at very low levels in lung, thymus and...